Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 8/20 | 0.41 |
| ▸ | CASP3 | P42574 | 3/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | KLK7 | P49862 | 1/20 | 0.36 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7437226 | 0.90 | CASP3 (0.49) | CASP1CASP3 | |
| SCHEMBL7443609 | 0.88 | CASP1 (0.42) | CASP1SYKMAPTATMKLK7 | |
| SCHEMBL7442691 | 0.87 | CASP1 (0.46) | CASP1CASP3SYKOPRK1MAPT | |
| SCHEMBL7435672 | 0.87 | ATM (0.44) | CASP1SYKMAPTATMKLK7 | |
| SCHEMBL7441581 | 0.86 | CASP1 (0.40) | CASP1CASP3P2RX7SYKMAPT | |
| SCHEMBL7438485 | 0.85 | CYP1A2 (0.44) | CASP1CASP3P2RX7SYKMAPT | |
| SCHEMBL7433669 | 0.85 | ATM (0.43) | CASP1SYKMAPTATMKLK7 | |
| SCHEMBL7438347 | 0.85 | CASP1 (0.41) | CASP1SYKMAPTATMKLK7 | |
| SCHEMBL7441638 | 0.84 | CASP1 (0.46) | CASP1SYKATMKLK7KLK5 | |
| SCHEMBL7439592 | 0.84 | CASP1 (0.39) | CASP1CASP3P2RX7SYKMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710153-A | INTERLEUKIN CONVERTING ENZYME INHIBITORS | ONO PHRAMACEUTICAL CO., LTD. (JP) | 1998-01-20 | — | — | US | disclosed |
| EP-0761680-A2 | Tetrazole compounds having Interleukin-1beta converting enzyme inhibitory activity | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-03-12 | — | — | EP | disclosed |