Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 3/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.44 |
| ▸ | FYN | P06241 | 2/20 | 0.42 |
| ▸ | QDPR | P09417 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | CDK7 | P50613 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1027176 | 0.83 | ASIC3 (0.59) | FYNLMNAMAPTHSD17B1HSD17B2 | |
| SCHEMBL30574378 | 0.83 | ASIC3 (0.59) | FYNLMNAMAPTHSD17B1HSD17B2 | |
| SCHEMBL1071219 | 0.81 | CCR1 (0.48) | LMNACDK5HSD17B1HSD17B2CDK5R1 | |
| SCHEMBL10324727 | 0.79 | LMNA (0.55) | PDGFRBPDGFRAQDPRLMNAMAPT | |
| SCHEMBL27157236 | 0.79 | NPC1 (0.56) | FYNMAPTHSD17B1HSD17B2MAPKAPK2 | |
| SCHEMBL21228520 | 0.79 | MAPT (0.56) | FYNLMNAMAPTHSD17B1HSD17B2 | |
| SCHEMBL9131899 | 0.79 | CCR1 (0.46) | LMNACDK5HSD17B1HSD17B2PIK3CA | |
| SCHEMBL12463924 | 0.76 | HRH4 (0.51) | PDGFRAFYNCDK5HSD17B1HSD17B2 | |
| SCHEMBL2077041 | 0.76 | LMNA (0.56) | LMNAMAPTDYRK1AGSK3B | |
| SCHEMBL12335822 | 0.75 | NPC1 (0.59) | FYNMAPTDYRK1ACLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183239-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | G.D. SEARLE & CO. (US) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000069821-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | G.D. SEARLE & CO. (US) | 2000-11-23 | — | — | WO | disclosed |