Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HRH2 | P25021 | 5/20 | 0.41 |
| ▸ | PTAFR | P25105 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7433578 | 0.94 | EPHX2 (0.43) | SMN1; SMN2LMNAHRH2PTAFRHRH4 | |
| SCHEMBL9867649 | 0.93 | LMNA (0.49) | SMN1; SMN2LMNAHRH2HRH4NPC1 | |
| SCHEMBL9867011 | 0.91 | LMNA (0.43) | SMN1; SMN2LMNAHRH2HRH4NPC1 | |
| SCHEMBL10875814 | 0.89 | HRH2 (0.49) | SMN1; SMN2HRH2PTAFRHRH4EPHX2 | |
| SCHEMBL9865162 | 0.87 | GAA (0.44) | SMN1; SMN2LMNAHRH2MEN1KMT2A | |
| SCHEMBL9866012 | 0.87 | LMNA (0.53) | SMN1; SMN2LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL9865910 | 0.87 | KMT2A (0.43) | SMN1; SMN2LMNAHRH2NPC1RAB9A | |
| SCHEMBL9866425 | 0.87 | RAB9A (0.42) | SMN1; SMN2LMNAHRH2HRH4NPC1 | |
| SCHEMBL10875704 | 0.87 | PTAFR (0.51) | HRH2PTAFRHRH4EPHX2ALDH1A1 | |
| SCHEMBL9867640 | 0.86 | SCN5A (0.45) | SMN1; SMN2LMNAHRH2HRH4EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0448765-B1 | Use of guanidine derivatives for the manufacture of a medicament with NPY-antagonistic activity | HEUMANN PHARMA GMBH & CO (DE) | 1994-08-17 | — | — | EP | disclosed |
| EP-0448765-A1 | Use of guanidine derivatives for the manufacture of a medicament with NPY-antagonistic activity | HEUMANN PHARMA GMBH & CO (DE) | 1991-10-02 | — | — | EP | disclosed |
| US-5021431-A | H-1 antagonist, h-2 agonist for treating hypertension, cardiac disease or arterial occlusion | HEUMANN PHARMA GMBH & CO. (DE) | 1991-06-04 | — | — | US | disclosed |
| EP-0199845-A1 | Imidazolylalkylguanidin derivatives, process for their preparation and pharmaceutical compositions containing them | HEUMANN PHARMA GMBH & CO (DE) | 1986-11-05 | — | — | EP | disclosed |