Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 2/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7437764 | 0.86 | CCNC (0.43) | NPSR1LMNACCNCCDK8CDK19 | |
| SCHEMBL7437761 | 0.86 | CCNC (0.43) | NPSR1LMNACCNCCDK8CDK19 | |
| SCHEMBL7415050 | 0.81 | NPSR1 (0.56) | NPSR1LMNAALDH1A1KDM4EPOLB | |
| SCHEMBL7441294 | 0.77 | NPSR1 (0.39) | NPSR1LMNAALDH1A1KDM4EPOLB | |
| SCHEMBL7442946 | 0.76 | NPSR1 (0.39) | NPSR1LMNAALDH1A1KDM4EPOLB | |
| SCHEMBL7434349 | 0.76 | CCNC (0.43) | NPSR1LMNACCNCCDK8CDK19 | |
| SCHEMBL7437156 | 0.71 | LMNA (0.38) | NPSR1LMNAALDH1A1KDM4EPOLB | |
| SCHEMBL7437153 | 0.71 | LMNA (0.38) | NPSR1LMNAALDH1A1KDM4EPOLB | |
| SCHEMBL7440268 | 0.65 | HPGD (0.33) | LMNAALDH1A1HPGDTSHR | |
| SCHEMBL7429710 | 0.64 | HPGD (0.32) | NPSR1LMNAALDH1A1HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6143773-A | Substituted thienobenzisoxazole derivatives for enhancing cognition | MERCK SHARP & DOHME LIMITED (GB) | 2000-11-07 | — | — | US | disclosed |