Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7437156 | 1.00 | LMNA (0.38) | LMNANPSR1ALDH1A1POLBHSD17B10 | |
| SCHEMBL7442946 | 0.90 | NPSR1 (0.39) | LMNANPSR1ALDH1A1POLBHPGD | |
| SCHEMBL7430600 | 0.88 | NPSR1 (0.38) | LMNANPSR1ALDH1A1POLBHSD17B10 | |
| SCHEMBL7416886 | 0.79 | NPSR1 (0.57) | LMNANPSR1ALDH1A1POLBHSD17B10 | |
| SCHEMBL7437284 | 0.79 | LMNA (0.33) | LMNANPSR1 | |
| SCHEMBL7437761 | 0.79 | CCNC (0.43) | LMNANPSR1ALDH1A1POLBKDM4E | |
| SCHEMBL7437764 | 0.79 | CCNC (0.43) | LMNANPSR1ALDH1A1POLBKDM4E | |
| SCHEMBL7429710 | 0.78 | HPGD (0.32) | LMNANPSR1ALDH1A1HPGD | |
| SCHEMBL7446073 | 0.76 | ALDH1A1 (0.33) | LMNANPSR1ALDH1A1POLBHSD17B10 | |
| SCHEMBL7443342 | 0.76 | CCNC (0.45) | LMNANPSR1ALDH1A1HSD17B10CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6143773-A | Substituted thienobenzisoxazole derivatives for enhancing cognition | MERCK SHARP & DOHME LIMITED (GB) | 2000-11-07 | — | — | US | disclosed |