Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 7/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL221158 | 0.71 | KDM4E (0.45) | TGFBR1 | |
| SCHEMBL8875116 | 0.66 | KDM4E (0.46) | — | |
| SCHEMBL632201 | 0.63 | — | — | |
| Ammonia Solution, Strong SCHEMBL28823448 | 0.61 | — | — | |
| Ethylene SCHEMBL28883508 | 0.60 | — | — | |
| SCHEMBL16242291 | 0.59 | KMO (0.47) | TGFBR1GABRG2GABRB3GABRA5GABRA3 | |
| Methyl Alcohol SCHEMBL21630012 | 0.58 | — | — | |
| Methylamine SCHEMBL4819184 | 0.58 | — | — | |
| SCHEMBL557932 | 0.57 | L3MBTL1 (0.47) | — | |
| SCHEMBL16390982 | 0.56 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430018-A2 | BENZOXAZOLONE DERIVATIVES AS ALDOSTERONE SYMTHASE INHIBITORS | Novartis AG (CH) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010130773-A2 | BENZOXAZOLONE DERIVATIVES AS ALDOSTERONE SYMTHASE INHIBITORS | NOVARTIS AG (CH) | 2010-11-18 | — | — | WO | disclosed |