Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.44 |
| ▸ | NOS1 | P29475 | 1/20 | 0.44 |
| ▸ | NOS2 | P35228 | 1/20 | 0.44 |
| ▸ | POLQ | O75417 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | PIEZO1 | Q92508 | 1/20 | 0.36 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL147107 | 0.85 | NOS3 (0.47) | NOS3NOS1NOS2POLQHTT | |
| SCHEMBL17114858 | 0.81 | NOS3 (0.44) | NOS3NOS1NOS2POLQHTT | |
| SCHEMBL18682100 | 0.81 | NOS3 (0.48) | NOS3NOS1NOS2POLQHTT | |
| SCHEMBL15779383 | 0.81 | NOS3 (0.44) | NOS3NOS1NOS2POLQHTT | |
| Hydrochloric Acid SCHEMBL18524112 | 0.80 | NOS3 (0.43) | NOS3NOS1NOS2POLQHTT | |
| SCHEMBL20303604 | 0.79 | CES2 (0.43) | POLQPIEZO1CYP3A4IDO1CYP2D6 | |
| SCHEMBL936487 | 0.79 | NOS3 (0.48) | NOS3NOS1NOS2POLQHTT | |
| SCHEMBL1196343 | 0.77 | NOS3 (0.47) | NOS3NOS1NOS2POLQHTT | |
| SCHEMBL1125472 | 0.77 | NOS3 (0.47) | NOS3NOS1NOS2POLQHTT | |
| SCHEMBL18908921 | 0.77 | NOS3 (0.47) | NOS3NOS1NOS2POLQHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1240143-A1 | NEW MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. Carlsson Research AB (SE) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001046146-A1 | NEW MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2001-06-28 | — | — | WO | disclosed |