Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11454377 | 0.80 | POLB (0.33) | POLBKMT2A | |
| SCHEMBL11454376 | 0.80 | POLB (0.33) | POLBKMT2A | |
| SCHEMBL11454378 | 0.80 | POLB (0.33) | POLBKMT2A | |
| SCHEMBL7419275 | 0.79 | CYP19A1 (0.32) | HTT | |
| SCHEMBL7362669 | 0.75 | POLB (0.32) | POLBHTT | |
| SCHEMBL7362671 | 0.75 | POLB (0.32) | POLBHTT | |
| SCHEMBL6431140 | 0.75 | POLB (0.32) | POLBHTT | |
| SCHEMBL11198292 | 0.67 | ALDH1A1 (0.31) | POLB | |
| SCHEMBL11245438 | 0.66 | TP53 (0.34) | — | |
| SCHEMBL6095759 | 0.64 | POLB (0.42) | POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6071899-A | Azetidinone derivatives for the treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-06-06 | — | — | US | disclosed |
| EP-0788478-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-08-13 | — | — | EP | disclosed |
| WO-1996013484-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-05-09 | — | — | WO | disclosed |
| EP-0362622-B1 | Use of stable oxapenem-3-carboxylic acids for the manufacture of beta-lactamase inhibiting medicaments | LILLY CO ELI (US) | 1995-03-29 | — | — | EP | disclosed |
| EP-0301394-B1 | STABLE OXAPENEM-3-CARBOXYLIC ACIDS | Pfaendler, Hans Rudolf, Prof. Dr. (DE) | 1993-10-06 | — | — | EP | disclosed |
| US-5229381-A | Inhibitors of leukocyte enzyme elastase | MERCK & CO., INC. (US) | 1993-07-20 | — | — | US | disclosed |
| US-5108747-A | STABLE OXPENEM-3-CARBOXYLIC ACIDS AS BETA-LACTAMASE INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 1992-04-28 | — | — | US | disclosed |
| EP-0481671-A1 | New substituted azetidinones as anti-inflammatory and antidegenerative agents | MERCK & CO. INC. (US) | 1992-04-22 | — | — | EP | disclosed |
| US-5096899-A | Nonhydrolyzing oxapenicillins | BAYER AKTIENGESELLSCHAFT (DE) | 1992-03-17 | — | — | US | disclosed |
| EP-0199630-B1 | SUBSTITUTED AZETIDINONES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE FOR THE MANUFACTURE OF ANTI-INFLAMMATORY AND ANTIDEGENERATIVE MEDICAMENTS | MERCK & CO. INC. (US) | 1990-09-19 | — | — | EP | disclosed |
| EP-0362622-A1 | Use of stable oxapenem-3-carboxylic acids for the manufacture of beta-lactamase inhibiting medicaments | ELI LILLY AND COMPANY (US) | 1990-04-11 | — | — | EP | disclosed |
| EP-0337549-A1 | New substituted azetidinones as anti-inflammatory and antidegenerative agents | MERCK & CO. INC. (US) | 1989-10-18 | — | — | EP | disclosed |
| EP-0301394-A1 | Stable oxapenem-3-carboxylic acids | Pfaendler, Hans Rudolf, Prof. Dr. (DE) | 1989-02-01 | — | — | EP | disclosed |
| US-4683303-A | Reduction process for the preparation of 4-unsubstituted azetidin-2-ones | PFAENDLER HANS R (DE) | 1987-07-28 | — | — | US | disclosed |
| US-4680391-A | Substituted azetidinones as anti-inflammatory and antidegenerative agents | MERCK & CO., INC. (US) | 1987-07-14 | — | — | US | disclosed |
| EP-0199630-A1 | Substituted azetidinones, pharmaceutical compositions containing them, and their use for the manufacture of anti-inflammatory and antidegenerative medicaments | MERCK & CO. INC. (US) | 1986-10-29 | — | — | EP | disclosed |