Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CPT2 | P23786 | 1/20 | 0.31 |
| ▸ | ACLY | P53396 | 1/20 | 0.31 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28995293 | 0.76 | CPT2 (0.37) | GRM2GRM3TSHRCPT2ACLY | |
| SCHEMBL3979316 | 0.71 | ACLY (0.57) | GRM2GRM3CPT2ACLYHSPD1 | |
| SCHEMBL7437959 | 0.68 | ALDH1A1 (0.32) | TSHRGAA | |
| SCHEMBL6279850 | 0.68 | RNPEP (0.39) | GRM2GRM3CPT2ACLYHSPD1 | |
| SCHEMBL19285040 | 0.67 | TSHR (0.35) | TSHRBLMMEN1KMT2A | |
| SCHEMBL2291884 | 0.67 | TSHR (0.35) | TSHRBLMMEN1KMT2A | |
| SCHEMBL19285495 | 0.67 | TSHR (0.35) | TSHRBLMMEN1KMT2A | |
| SCHEMBL9655584 | 0.67 | ALDH1A1 (0.31) | TSHR | |
| SCHEMBL18538617 | 0.66 | GAA (0.44) | GRM2GRM3TSHRGAASMN1; SMN2 | |
| SCHEMBL11142356 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6344457-B1 | RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPOROSIS, CORNEAL ULCERATION, PERIODONTITIS, GINGIVITIS OR TUMOROUS INVASION AND METASTATIC PROLIFERATION, ATHEROSCLEROSIS, AIDS, CHRONIC INFLAMMATORY DISEASES OF THE INTESTINE | CHIESI FARMACEUTICI S.P.A. (IT) | 2002-02-05 | — | — | US | disclosed |