SCHEMBL7434158

SCHEMBL7434158

Oc1cccc(-c2ccc(CN3CCOCC3)cc2)c1

nearest known ligand 0.68

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 2/20 0.68
HDAC1 Q13547 1/20 0.56
CYP2D6 P10635 2/20 0.54
CYP2C19 P33261 2/20 0.54
CYP3A4 P08684 2/20 0.54
CYP2C9 P11712 2/20 0.54
NPC1 O15118 1/20 0.52
RAB9A P51151 1/20 0.52
ATM Q13315 1/20 0.52
JAK2 O60674 1/20 0.51
HSD17B1 P14061 2/20 0.50
HSD17B2 P37059 2/20 0.50
NCF1 P14598 1/20 0.50
PIK3R1 P27986 1/20 0.48
PIK3CA P42336 1/20 0.48
PDE4B Q07343 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
HPGD P15428 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7439516 0.86 SIGMAR1 (0.51) HRH3CYP2D6CYP2C19CYP3A4CYP2C9
SCHEMBL30118939 0.83 NCF1 (0.66) HRH3CYP2D6CYP2C19CYP3A4CYP2C9
SCHEMBL1928790 0.83 NCF1 (0.66) HRH3CYP2D6CYP2C19CYP3A4CYP2C9
4-(Biphenyl-4-Ylmethyl)Morpholine SCHEMBL1691308 0.82 HRH3 (0.85) HRH3HDAC1CYP2D6CYP2C19CYP3A4
SCHEMBL13376445 0.82 HRH3 (0.68) HRH3HDAC1CYP2D6CYP2C19NPC1
SCHEMBL21228249 0.81 PIK3CA (0.51) HRH3CYP2D6CYP2C19CYP3A4CYP2C9
SCHEMBL3719689 0.81 NCF1 (0.73) HRH3HDAC1CYP2D6CYP2C19CYP3A4
SCHEMBL31554953 0.81 HRH3 (0.60) HRH3HDAC1CYP2D6CYP2C9NPC1
SCHEMBL3719688 0.80 HRH3 (0.59) HRH3HDAC1NPC1RAB9AATM
SCHEMBL26378175 0.79 HRH3 (0.62) HRH3HDAC1CYP2D6CYP2C19NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019149205-A1 BENZOHETEROARYL DERIVATIVE AND PREPARATION METHOD AND MEDICAL APPLICATION THEREOF 江苏恒瑞医药股份有限公司 2019-08-08 WO disclosed
EP-0863755-A4 ANTITHROMBOTIC DIAMINES LILLY CO ELI (US) 1999-01-20 EP disclosed
EP-0863755-A1 ANTITHROMBOTIC DIAMINES ELI LILLY AND COMPANY (US) 1998-09-16 EP disclosed
WO-1997025033-A1 ANTITHROMBOTIC DIAMINES ELI LILLY AND COMPANY (US) 1997-07-17 WO disclosed