Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | TPMT | P51580 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | RXRA | P19793 | 1/20 | 0.46 |
| ▸ | RXRB | P28702 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | PLEC | Q15149 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL566208 | 0.87 | TPMT (0.44) | ALDH1A1TPMTRAB9AMEN1NPC1 | |
| SCHEMBL30988384 | 0.84 | ACE2 (0.49) | ALDH1A1TPMTKDM4EGAAMAPT | |
| SCHEMBL16080084 | 0.84 | ACE2 (0.49) | ALDH1A1TPMTKDM4EGAAMAPT | |
| SCHEMBL31721465 | 0.84 | ALDH1A1 (0.50) | ALDH1A1TPMTRAB9AMEN1NPC1 | |
| SCHEMBL10503509 | 0.82 | TPMT (0.47) | ALDH1A1TPMTKDM4EGAAMAPT | |
| SCHEMBL31370442 | 0.82 | TPMT (0.47) | ALDH1A1TPMTKDM4EGAAMAPT | |
| SCHEMBL2755400 | 0.81 | ALDH1A1 (0.56) | ALDH1A1TPMTRAB9AMEN1NPC1 | |
| SCHEMBL31291738 | 0.79 | CA1 (0.50) | ALDH1A1MEN1KMT2AKDM4EGAA | |
| SCHEMBL27914915 | 0.79 | CA1 (0.50) | ALDH1A1MEN1KMT2AKDM4EGAA | |
| Hydrochloric Acid SCHEMBL10354232 | 0.79 | ALDH1A1 (0.54) | ALDH1A1TPMTRAB9AMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092232-B1 | HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS FOR USE AGAINST CANCER AND VIRAL INFECTIONS | SAGIMET BIOSCIENCES INC (US) | 2022-03-09 | — | — | EP | disclosed |
| US-9994550-B2 | Heterocyclic modulators of lipid synthesis for use against cancer and viral infections | 3-V BIOSCIENCES, INC. (US) | 2018-06-12 | — | — | US | disclosed |
| US-9994550-B2 | Heterocyclic modulators of lipid synthesis for use against cancer and viral infections | 3-V BIOSCIENCES, INC. (US) | 2018-06-12 | — | — | US | disclosed |
| EP-3092232-A1 | HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS FOR USE AGAINST CANCER AND VIRAL INFECTIONS | 3-V Biosciences, Inc. (US) | 2016-11-16 | — | — | EP | disclosed |
| US-20160326141-A1 | HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS FOR USE AGAINST CANCER AND VIRAL INFECTIONS | SAGIMET BIOSCIENCES INC. | 2016-11-10 | — | — | US | disclosed |
| US-20160326141-A1 | HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS FOR USE AGAINST CANCER AND VIRAL INFECTIONS | SAGIMET BIOSCIENCES INC. | 2016-11-10 | — | — | US | disclosed |
| US-20160326141-A1 | HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS FOR USE AGAINST CANCER AND VIRAL INFECTIONS | SAGIMET BIOSCIENCES INC. | 2016-11-10 | — | — | US | disclosed |
| WO-2015105860-A9 | HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS FOR USE AGAINST CANCER AND VIRAL INFECTIONS | 3-V BIOSCIENCES, INC. (US) | 2016-02-04 | — | — | WO | disclosed |
| CN-103214480-B | Pyrazolopyridine alkynes benzene-like compounds and medicinal compositions thereof and application | GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH, CHINESE ACADEMY OF SCIENCES (CN) | 2015-12-16 | — | — | CN | disclosed |
| WO-2015105860-A1 | HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS FOR USE AGAINST CANCER AND VIRAL INFECTIONS | 3-V BIOSCIENCES, INC. (US) | 2015-07-16 | — | — | WO | disclosed |
| CN-104211639-A | Alkynyl heterocyclic compounds and application thereof | SHANGHAI INST MATERIA MEDICA | 2014-12-17 | — | — | CN | disclosed |
| CN-103214480-A | Pyrazolopyridines alkynylbenzene compound and medicinal composition and application | GUANGZHOU INST BIOMED & HEALTH | 2013-07-24 | — | — | CN | disclosed |
| CN-1826310-B | Novel aminobenzophenone compounds | LEO PHARMA AS | 2010-07-21 | — | — | CN | disclosed |
| CN-101437800-A | Compounds and compositions as HEDGEHOG pathway modulators | IRM LLC (BM) | 2009-05-20 | — | — | CN | disclosed |
| CN-1826310-A | Novel aminobenzophenone compounds | LEO PHARMA AS (DK) | 2006-08-30 | — | — | CN | disclosed |
| CN-1092410-A | Inhibitors of HIV protease as the treatment AIDS | LILLY CO ELI (US) | 1994-09-21 | — | — | CN | disclosed |
| EP-0609625-A1 | Inhibitors of HIV protease useful for the treatment of AIDS | ELI LILLY AND COMPANY (US) | 1994-08-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160326141-A1 | HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS FOR USE AGAINST CANCER AND VIRAL INFECTIONS | FASN, FADS1, FADS2 | ALDH1A1 1328/4885TPMT 605/4885RAB9A 3166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.