Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 13/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | HPGD | P15428 | 7/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2805779 | 0.83 | KDM4E (1.00) | KDM4ETDP1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL29415434 | 0.83 | KDM4E (1.00) | KDM4ETDP1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL14533466 | 0.80 | RAB9A (0.60) | KDM4EALDH1A1HPGDHSD17B10RAB9A | |
| SCHEMBL8183478 | 0.80 | SIRT1 (0.54) | KDM4EALDH1A1HPGD | |
| SCHEMBL6964299 | 0.79 | KDM4E (0.57) | KDM4ETDP1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL10050059 | 0.79 | KDM4E (0.77) | KDM4EALDH1A1HPGDHSD17B10GAA | |
| SCHEMBL4895906 | 0.79 | KDM4E (0.72) | KDM4ETDP1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL30602834 | 0.79 | KDM4E (0.57) | KDM4ETDP1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL15782866 | 0.78 | KDM4E (0.63) | KDM4ETDP1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL29950909 | 0.78 | KDM4E (1.00) | KDM4ETDP1ALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0458636-B1 | Antiemetic and migraine suppressing heterocyclic compounds and pharmaceutical compositions containing them | KYOWA HAKKO KOGYO KK (JP) | 1995-07-12 | — | — | EP | disclosed |
| US-5248684-A | CERTAIN 2-OXO-QUINOLINE CARBOXYLATES OR CORRESPONDING CARBOXAMIDES USEFUL AS ANTI-EMETICS AND SUPPRESSANTS OF MIGRAINE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-09-28 | — | — | US | disclosed |
| EP-0458636-A1 | Antiemetic and migraine suppressing heterocyclic compounds and pharmaceutical compositions containing them | KYOWA HAKKO KOGYO CO., LTD (JP) | 1991-11-27 | — | — | EP | disclosed |