Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR132 | Q9UNW8 | 7/20 | 0.56 |
| ▸ | ACE | P12821 | 3/20 | 0.54 |
| ▸ | MME | P08473 | 1/20 | 0.54 |
| ▸ | CPA1 | P15085 | 1/20 | 0.54 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | CTSB | P07858 | 2/20 | 0.51 |
| ▸ | CTSL | P07711 | 1/20 | 0.51 |
| ▸ | CTSS | P25774 | 1/20 | 0.51 |
| ▸ | CTSK | P43235 | 1/20 | 0.51 |
| ▸ | GPR34 | Q9UPC5 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | CMKLR2 | P46091 | 1/20 | 0.49 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.48 |
| ▸ | CTSG | P08311 | 1/20 | 0.48 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.48 |
| ▸ | CMA1 | P23946 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7434379 | 1.00 | GPR132 (0.56) | GPR132ACEMMECPA1ACE2 | |
| SCHEMBL10816310 | 0.89 | GPR132 (0.66) | GPR132ACEMMECPA1ACE2 | |
| SCHEMBL7439848 | 0.83 | F10 (0.55) | GPR132ACEMMECPA1ACE2 | |
| SCHEMBL7439860 | 0.83 | F10 (0.55) | GPR132ACEMMECPA1ACE2 | |
| SCHEMBL23279751 | 0.83 | ACE (0.58) | GPR132ACECTSBCTSLCTSS | |
| SCHEMBL1123234 | 0.82 | GPR132 (0.71) | GPR132GPR34PTPN1CMKLR2CMKLR1 | |
| SCHEMBL1123282 | 0.80 | PTPN1 (0.58) | GPR132ACEMMECPA1ACE2 | |
| SCHEMBL11037416 | 0.79 | GPR132 (0.66) | GPR132ACEPTPN1CMKLR2CMKLR1 | |
| SCHEMBL5921800 | 0.78 | GPR132 (0.62) | GPR132ACEPTPN1CMKLR2CMKLR1 | |
| SCHEMBL5921805 | 0.78 | GPR132 (0.62) | GPR132ACEPTPN1CMKLR2CMKLR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4873253-A | Phenylalanine derivative and proteinase inhibitor | Okamoto, Shosuke (JP) | 1989-10-10 | — | — | US | disclosed |
| EP-0284632-A1 | Phenylalanine derivative and proteinase inhibitor | Okamoto, Shosuke (JP) | 1988-10-05 | — | — | EP | disclosed |