Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB1 | P20618 | 2/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.40 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.40 |
| ▸ | CTSL | P07711 | 3/20 | 0.38 |
| ▸ | CTSK | P43235 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7303044 | 0.94 | PSMB1 (0.44) | PSMB1PSMB5PSMB2CTSLCTSK | |
| SCHEMBL7312640 | 0.91 | PSMB1 (0.44) | PSMB1PSMB5PSMB2CTSLCTSK | |
| SCHEMBL7304423 | 0.91 | PSMB1 (0.48) | PSMB1PSMB5PSMB2CTSLCTSK | |
| SCHEMBL7307063 | 0.91 | PSMB1 (0.48) | PSMB1PSMB5PSMB2CTSLCTSK | |
| SCHEMBL7433236 | 0.90 | PSMB1 (0.46) | PSMB1PSMB5PSMB2CTSLCTSK | |
| SCHEMBL7303213 | 0.88 | PSMB1 (0.41) | PSMB1PSMB5PSMB2CTSLCTSK | |
| SCHEMBL7435130 | 0.88 | CAPN1 (0.47) | CTSLCTSKCTSBCAPN1 | |
| SCHEMBL7314124 | 0.88 | CAPN1 (0.47) | CTSLCTSKCTSBCAPN1 | |
| SCHEMBL7308188 | 0.87 | PSMB1 (0.44) | PSMB1PSMB5PSMB2CTSLCTSK | |
| SCHEMBL7303779 | 0.87 | PSMB1 (0.44) | PSMB1PSMB5PSMB2CTSLCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0525420-B1 | Pseudopeptides and dipeptides characterised by a substituted methyl ketone moiety at the C-terminus as thiol protease inhibitors | MITSUBISHI CHEM CORP (JP) | 1999-05-12 | — | — | EP | disclosed |
| US-5834508-A | PROTEASE ENZYME INHIBITORS; MUSCLE DISORDERS | MITSUBISHI CHEMICAL CORPORATION (JP) | 1998-11-10 | — | — | US | disclosed |
| US-5639783-A | POTENT PROTEASE INHIBITOR FOR TREATING MUSCULAR, NERVOUS SYSTEM DISEASES | MITSUBISHI CHEMICAL CORPORATION (JP) | 1997-06-17 | — | — | US | disclosed |