Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB1 | P20618 | 2/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.41 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 3/20 | 0.38 |
| ▸ | CTSK | P43235 | 2/20 | 0.38 |
| ▸ | NMBR | P28336 | 1/20 | 0.37 |
| ▸ | FCER2 | P06734 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7312640 | 0.93 | PSMB1 (0.44) | PSMB1PSMB5PSMB2ALDH1A1POLB | |
| SCHEMBL7304423 | 0.93 | PSMB1 (0.48) | PSMB1PSMB5PSMB2CTSLCTSK | |
| SCHEMBL7307063 | 0.93 | PSMB1 (0.48) | PSMB1PSMB5PSMB2CTSLCTSK | |
| SCHEMBL7303357 | 0.89 | CTSS (0.46) | PSMB1PSMB5PSMB2ALDH1A1POLB | |
| SCHEMBL7433236 | 0.89 | PSMB1 (0.46) | PSMB1PSMB5PSMB2ALDH1A1CTSL | |
| SCHEMBL7308188 | 0.89 | PSMB1 (0.44) | PSMB1PSMB5PSMB2CTSLCTSK | |
| SCHEMBL7303779 | 0.89 | PSMB1 (0.44) | PSMB1PSMB5PSMB2CTSLCTSK | |
| SCHEMBL7340910 | 0.88 | PSMB1 (0.42) | PSMB1PSMB5PSMB2ALDH1A1POLB | |
| SCHEMBL7340905 | 0.88 | PSMB1 (0.42) | PSMB1PSMB5PSMB2ALDH1A1POLB | |
| SCHEMBL7437241 | 0.88 | ALDH1A1 (0.39) | PSMB1PSMB5PSMB2ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0525420-B1 | Pseudopeptides and dipeptides characterised by a substituted methyl ketone moiety at the C-terminus as thiol protease inhibitors | MITSUBISHI CHEM CORP (JP) | 1999-05-12 | — | — | EP | disclosed |
| US-5834508-A | PROTEASE ENZYME INHIBITORS; MUSCLE DISORDERS | MITSUBISHI CHEMICAL CORPORATION (JP) | 1998-11-10 | — | — | US | disclosed |
| US-5639783-A | POTENT PROTEASE INHIBITOR FOR TREATING MUSCULAR, NERVOUS SYSTEM DISEASES | MITSUBISHI CHEMICAL CORPORATION (JP) | 1997-06-17 | — | — | US | disclosed |
| EP-0525420-A1 | Pseudopeptides and dipeptides characterised by a substituted methyl ketone moiety at the C-terminus as thiol protease inhibitors | Mitsubishi Chemical Corporation (JP) | 1993-02-03 | — | — | EP | disclosed |