Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.31 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.31 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13262638 | 0.81 | CRBN (0.40) | KDM4ELMNACYP2C19TSHRNPSR1 | |
| SCHEMBL7436641 | 0.80 | ELANE (0.39) | LMNATSHRNPSR1 | |
| SCHEMBL3079790 | 0.77 | SMN1; SMN2 (0.46) | KDM4ELMNACYP2C19TSHRNPSR1 | |
| SCHEMBL7439817 | 0.77 | KDM4E (0.59) | KDM4ELMNACYP2C19TSHRNPSR1 | |
| SCHEMBL7438104 | 0.74 | — | — | |
| SCHEMBL11079770 | 0.74 | LMNA (0.61) | KDM4ELMNACYP2C19TSHRNPSR1 | |
| SCHEMBL7446299 | 0.72 | KDM4E (0.35) | KDM4ELMNACYP2C19TSHRNPSR1 | |
| SCHEMBL26415062 | 0.71 | KDM4E (0.34) | KDM4ELMNACYP2C19TSHRNPSR1 | |
| SCHEMBL21557294 | 0.71 | KDM4E (0.47) | KDM4ELMNACYP2C19TSHRNPSR1 | |
| SCHEMBL2478278 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6066666-A | OPTIONALLY N-SUBSTITUTED 3-MONO- AND DI-SUBSTITUTED 2-PYRROLIDINONES AND THIOLACTAM ANALOGS; TREAT SEIZURES, ANXIETY, AND ENHANCING 4-AMINOBUTYRIC ACID (GABA)-INDUCED CHLORIDE CURRENTS AT GABA RECEPTOR/IONOPHORE COMPLEX | WASHINGTON UNIVERSITY (US) | 2000-05-23 | — | — | US | disclosed |
| US-5776959-A | Anticonvulsant and anxiolytic lactam and thiolactam derivatives | WASHINGTON UNIVERSITY (US) | 1998-07-07 | — | — | US | disclosed |