Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6493984 | 0.85 | — | — | |
| SCHEMBL8439728 | 0.77 | PDE5A (0.31) | PDE5A | |
| SCHEMBL39411 | 0.74 | — | — | |
| SCHEMBL7434885 | 0.70 | CDK1 (0.34) | — | |
| SCHEMBL6729337 | 0.69 | KMT2A (0.46) | — | |
| SCHEMBL9350812 | 0.69 | — | — | |
| Methoxymethane SCHEMBL28440091 | 0.67 | PDE4A (0.33) | PDE5A | |
| SCHEMBL982396 | 0.66 | TDP1 (0.32) | — | |
| SCHEMBL27823063 | 0.66 | LIPG (0.40) | — | |
| SCHEMBL11413980 | 0.63 | ACP3 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5580871-A | FOR TREATMENT OF CONGESTIVE HEART FAILURE | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-03 | — | — | US | disclosed |
| US-5432188-A | Treating congestive heart failure | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-07-11 | — | — | US | disclosed |
| US-5166147-A | Congestive heart failure | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1992-11-24 | — | — | US | disclosed |