Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9146288 | 0.89 | POLB (0.44) | KDM4EALDH1A1LMNABRD4HPGD | |
| SCHEMBL9146083 | 0.89 | TP53 (0.42) | KDM4EALDH1A1LMNABRD4HPGD | |
| Hydrochloric Acid SCHEMBL9146013 | 0.85 | KDM4E (0.41) | KDM4EALDH1A1LMNABRD4HPGD | |
| Hydrochloric Acid SCHEMBL9142613 | 0.85 | HTR1A (0.48) | KDM4EALDH1A1LMNABRD4HPGD | |
| Hydrochloric Acid SCHEMBL9142777 | 0.84 | KDM4E (0.57) | KDM4EALDH1A1LMNAHPGDF2 | |
| SCHEMBL9141800 | 0.83 | TP53 (0.54) | KDM4EALDH1A1LMNAHPGDTP53 | |
| SCHEMBL9144722 | 0.82 | KDM4E (0.61) | KDM4EALDH1A1LMNAHPGDTP53 | |
| Hydrochloric Acid SCHEMBL9141592 | 0.81 | KDM4E (0.41) | KDM4EALDH1A1LMNABRD4HPGD | |
| Hydrochloric Acid SCHEMBL9143815 | 0.80 | TP53 (0.48) | KDM4EALDH1A1LMNABRD4HPGD | |
| SCHEMBL9144644 | 0.80 | THRB (0.54) | KDM4EALDH1A1LMNAHPGDTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590455-B1 | Antiarrhythmic and cardioprotective substituted 1(2H)-isoquinolines, process for their production, medicament containing them and their use for the production of a medicament for combating heart failures | HOECHST AG (DE) | 2000-12-27 | — | — | EP | disclosed |
| US-5416094-A | Antiarrhythmic and cardioprotective substituted -1(2H)isoquinolines, medicament containing them, and their use for combating heart failures | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-05-16 | — | — | US | disclosed |
| EP-0590455-A1 | Antiarrhythmic and cardioprotective substituted -1(2H)Isoquinolines, process for their production, medicament containing them and their use for the production of a medicament for combating heart failures | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |