Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ATM | Q13315 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14833601 | 0.80 | CHRM1 (0.39) | KDM4EL3MBTL1PARP1ALDH1A1POLB | |
| SCHEMBL27376633 | 0.70 | PARP1 (0.31) | PARP1 | |
| SCHEMBL7431353 | 0.69 | HTR3E (0.38) | — | |
| SCHEMBL25376150 | 0.69 | CYP2B6 (0.30) | — | |
| SCHEMBL7435203 | 0.65 | PARP1 (0.36) | KDM4EL3MBTL1PARP1ALDH1A1AURKA | |
| SCHEMBL7268507 | 0.63 | KDM4E (0.41) | KDM4EL3MBTL1ALDH1A1KMT2AMEN1 | |
| SCHEMBL6835175 | 0.61 | MCL1 (0.42) | KDM4EPARP1ALDH1A1KMT2AMEN1 | |
| SCHEMBL6834809 | 0.61 | MEN1 (0.39) | KDM4EPARP1ALDH1A1AURKARPS6KB1 | |
| SCHEMBL6837082 | 0.61 | MEN1 (0.41) | PARP1KMT2AMEN1 | |
| SCHEMBL6135290 | 0.61 | ATM (0.61) | KDM4EL3MBTL1PARP1ALDH1A1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0403261-A2 | Amide derivatives | GLAXO GROUP LIMITED (GB) | 1990-12-19 | — | — | EP | disclosed |