Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 18/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4637252 | 0.87 | PDE4A (0.60) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7908615 | 0.84 | PDE4A (0.74) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7436426 | 0.83 | PPARG (0.54) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL2995451 | 0.82 | PDE4A (0.62) | PDE4APDE4DPDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL2503057 | 0.82 | PDE4A (0.53) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL2988958 | 0.81 | PDE4A (0.63) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL4637671 | 0.81 | PDE4A (0.61) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL2989802 | 0.81 | PDE4A (0.61) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL8285881 | 0.81 | PDE4A (0.59) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7317892 | 0.81 | PDE4A (0.59) | PDE4APDE4DPDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0942902-A2 | NOVEL IMMUNOTHERAPEUTIC IMIDES/AMIDES | CELGENE CORPORATION (US) | 1999-09-22 | — | — | EP | disclosed |
| WO-1998024763-A2 | IMMUNOTHERAPEUTIC IMIDES/AMIDES AS PDE IV AND TNF INHIBITORS | CELGENE CORPORATION (US) | 1998-06-11 | — | — | WO | disclosed |
| US-5703098-A | INHIBITORS OF CYTOKINES INCLUDING TUMOR NECROSIS FACTOR | CELGENE CORPORATION (US) | 1997-12-30 | — | — | US | disclosed |