Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 18/20 | 0.60 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7435222 | 0.87 | PDE4A (0.55) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL2989802 | 0.85 | PDE4A (0.61) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL7317892 | 0.85 | PDE4A (0.59) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL8285881 | 0.85 | PDE4A (0.59) | PDE4APDE4BPDE4DPDE4C | |
| Hydrochloric Acid SCHEMBL2503057 | 0.84 | PDE4A (0.53) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL1194607 | 0.84 | PDE4A (0.62) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL2995451 | 0.84 | PDE4A (0.62) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL2988958 | 0.83 | PDE4A (0.63) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL4637671 | 0.83 | PDE4A (0.61) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL7325901 | 0.83 | PDE4A (0.54) | PDE4APDE4BPDE4DPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1468991-B1 | Imides as PDE III, PDE IV and TNF inhibitors | CELGENE CORP (US) | 2008-02-20 | — | — | EP | disclosed |
| EP-1468991-A1 | Imides as PDE III, PDE IV and TNF inhibitors | CELGENE CORPORATION (US) | 2004-10-20 | — | — | EP | disclosed |
| EP-0874819-B1 | IMIDES AS PDE III, PDE IV AND TNF INHIBITORS | CELGENE CORP (US) | 2004-05-26 | — | — | EP | disclosed |
| CN-1092640-C | Imides as PDE III, PDE IV and TNF inhibitors | CELGENE CORP (US) | 2002-10-16 | — | — | CN | disclosed |
| CN-1206405-A | Imides as PDE III, PDE IV and TNF inhibitors | CELGENE CORP (US) | 1999-01-27 | — | — | CN | disclosed |
| EP-0874819-A1 | IMIDES AS PDE III, PDE IV AND TNF INHIBITORS | CELGENE CORPORATION (US) | 1998-11-04 | — | — | EP | disclosed |
| US-5728844-A | INHIBITORS OF TUMOR NECROSIS AND PHOSPHODIESTERASE | CELGENE CORPORATION (US) | 1998-03-17 | — | — | US | disclosed |
| WO-1997023457-A1 | IMIDES AS PDE III, PDE IV AND TNF INHIBITORS | CELGENE CORPORATION (US) | 1997-07-03 | — | — | WO | disclosed |