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SCHEMBL7435285

SCHEMBL7435285

O=C(NCc1ccc(S(=O)(=O)N2CCN(C(=O)c3ccco3)CC2)s1)c1ccc(Cl)cc1.O=C(NCc1ccc(S(=O)(=O)N2CCN(CC(=O)N3CCCC3)CC2)s1)c1ccc(Cl)cc1.O=C(NCc1ccc(S(=O)(=O)N2CCN(CC(=O)N3CCOCC3)CC2)s1)c1ccc(Cl)cc1.O=C(NCc1ccc(S(=O)(=O)N2CCN(Cc3ccncc3)CC2)s1)c1ccc(Cl)cc1.O=C(NCc1ccc(S(=O)(=O)N2CCN(c3ccc(O)cc3)CC2)s1)c1ccc(Cl)cc1.O=C(NCc1ccc(S(=O)(=O)N2CCN(c3ccc([N+](=O)[O-])cc3)CC2)s1)c1ccc(Cl)cc1

nearest known ligand 0.40

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ BCL2 P10415 1/20 0.40
▸ BCL2L1 Q07817 1/20 0.40
▸ POLB P06746 2/20 0.39
▸ KMT2A Q03164 1/20 0.39
▸ TDP1 Q9NUW8 1/20 0.39
▸ ALDH1A1 P00352 2/20 0.38
▸ NPC1 O15118 2/20 0.37
▸ MAPT P10636 4/20 0.36
▸ SMN1; SMN2 Q16637 3/20 0.36
▸ LMNA P02545 2/20 0.36
▸ MAPK9 P45984 1/20 0.36
▸ MAPK10 P53779 1/20 0.36
▸ RAB9A P51151 1/20 0.36
▸ TP53 P04637 1/20 0.36
▸ HPGDS O60760 1/20 0.36
▸ NAMPT P43490 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7435212 0.82 MAPK9 (0.48) BCL2BCL2L1POLBKMT2AALDH1A1
SCHEMBL4965751 0.80 SMN1; SMN2 (0.53) BCL2BCL2L1POLBKMT2ATDP1
SCHEMBL2422063 0.76 MAPK9 (0.52) BCL2BCL2L1KMT2ATDP1ALDH1A1
SCHEMBL2428407 0.75 MAPK9 (0.53) BCL2BCL2L1POLBKMT2AALDH1A1
SCHEMBL2422099 0.75 ALDH1A1 (0.59) POLBKMT2AALDH1A1NPC1MAPT
SCHEMBL2421342 0.74 MAPK9 (0.56) BCL2BCL2L1POLBKMT2AALDH1A1
SCHEMBL2423853 0.74 MAPK9 (0.54) BCL2BCL2L1POLBKMT2ATDP1
SCHEMBL2422619 0.73 MAPK9 (0.52) KMT2ATDP1ALDH1A1MAPTSMN1; SMN2
SCHEMBL2428129 0.72 MAPK9 (0.56) BCL2BCL2L1POLBKMT2ATDP1
SCHEMBL3480648 0.70 MAPK9 (0.60) BCL2BCL2L1KMT2AALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1218374-A1 PHARMACEUTICALLY ACTIVE SULFONAMIDE DERIVATIVES Applied Research Systems ARS Holding N.V. (AN) 2002-07-03 — — EP claimed
WO-2001023378-A1 PHARMACEUTICALLY ACTIVE SULFONAMIDE DERIVATIVES APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) 2001-04-05 — — WO claimed
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