Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 12/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 12/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 12/20 | 0.56 |
| ▸ | CCR1 | P32246 | 1/20 | 0.44 |
| ▸ | CCR8 | P51685 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7434938 | 0.88 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DCCR1 | |
| SCHEMBL7431186 | 0.86 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4DCCR1 | |
| SCHEMBL7445568 | 0.82 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DCCR1 | |
| SCHEMBL7437244 | 0.82 | CCR1 (0.50) | PDE4APDE4BPDE4CPDE4DCCR1 | |
| SCHEMBL7448426 | 0.81 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DCCR1 | |
| SCHEMBL5257490 | 0.80 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL16743118 | 0.79 | CCR1 (0.50) | PDE4APDE4BPDE4CPDE4DCCR1 | |
| SCHEMBL6181570 | 0.79 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4DTP53 | |
| SCHEMBL7445385 | 0.79 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DCCR1 | |
| SCHEMBL6180068 | 0.78 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691966-B1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX INC (US) | 1998-09-09 | — | — | EP | disclosed |
| EP-0691966-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1996-01-17 | — | — | EP | disclosed |
| US-5455252-A | Antiinflammatory agent, immunosuppressant, antiallergen, skin disorders, bronchodilator, analgesic | SYNTEX (U.S.A.) INC. (US) | 1995-10-03 | — | — | US | disclosed |
| WO-1994022852-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1994-10-13 | — | — | WO | disclosed |