Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 4/20 | 0.50 |
| ▸ | CCR8 | P51685 | 4/20 | 0.50 |
| ▸ | CCR5 | P51681 | 2/20 | 0.50 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.50 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | DHFR | P00374 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 2/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.40 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7438319 | 0.87 | CCR1 (0.47) | CCR1CCR8CCR5PSMD14COPS5 | |
| SCHEMBL7437210 | 0.85 | CCR1 (0.53) | CCR1CCR8CCR5PSMD14COPS5 | |
| SCHEMBL7440046 | 0.82 | PDE4A (0.54) | CCR1CCR8CCR5PSMD14COPS5 | |
| SCHEMBL7435290 | 0.82 | PDE4A (0.56) | CCR1CCR8L3MBTL1DHFRALDH1A1 | |
| SCHEMBL7434171 | 0.82 | PDE4A (0.49) | CCR1CCR8L3MBTL1DHFRALDH1A1 | |
| SCHEMBL7440672 | 0.80 | CCR1 (0.57) | CCR1CCR8CCR5PSMD14COPS5 | |
| SCHEMBL7445247 | 0.79 | CCR1 (0.44) | CCR1CCR8CCR5L3MBTL1DHFR | |
| SCHEMBL31135866 | 0.77 | PSMD14 (0.62) | CCR1CCR8CCR5PSMD14COPS5 | |
| SCHEMBL11087820 | 0.77 | PSMD14 (0.62) | CCR1CCR8CCR5PSMD14COPS5 | |
| SCHEMBL7444931 | 0.77 | PDE4A (0.52) | CCR1CCR8L3MBTL1DHFRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691966-B1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX INC (US) | 1998-09-09 | — | — | EP | disclosed |
| EP-0691966-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1996-01-17 | — | — | EP | disclosed |
| US-5455252-A | Antiinflammatory agent, immunosuppressant, antiallergen, skin disorders, bronchodilator, analgesic | SYNTEX (U.S.A.) INC. (US) | 1995-10-03 | — | — | US | disclosed |
| WO-1994022852-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1994-10-13 | — | — | WO | disclosed |