Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 7/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | CCR8 | P51685 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.37 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.37 |
| ▸ | TOP1 | P11387 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | UGT2B7 | P16662 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7434938 | 0.90 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DAKR1C3 | |
| SCHEMBL7442526 | 0.84 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7438319 | 0.81 | CCR1 (0.47) | PDE4APDE4BPDE4CPDE4DCCR1 | |
| SCHEMBL7435290 | 0.79 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DCCR1 | |
| SCHEMBL29870078 | 0.78 | MET (0.47) | AKR1C3AKR1C2CCR1CCR8UGT2B7 | |
| SCHEMBL28098226 | 0.78 | MET (0.47) | AKR1C3AKR1C2CCR1CCR8UGT2B7 | |
| SCHEMBL6181290 | 0.76 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DAKR1C3 | |
| SCHEMBL7431186 | 0.76 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4DCCR1 | |
| SCHEMBL7445176 | 0.76 | CCR1 (0.41) | PDE4APDE4BPDE4CPDE4DCCR1 | |
| SCHEMBL7445568 | 0.74 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DCCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691966-B1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX INC (US) | 1998-09-09 | — | — | EP | disclosed |
| EP-0691966-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1996-01-17 | — | — | EP | disclosed |
| US-5455252-A | Antiinflammatory agent, immunosuppressant, antiallergen, skin disorders, bronchodilator, analgesic | SYNTEX (U.S.A.) INC. (US) | 1995-10-03 | — | — | US | disclosed |
| WO-1994022852-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1994-10-13 | — | — | WO | disclosed |