⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7431565 | 0.97 | CRBN (0.39) | — | |
| SCHEMBL7432250 | 0.97 | CRBN (0.39) | — | |
| SCHEMBL7430101 | 0.97 | — | — | |
| SCHEMBL745074 | 0.92 | — | — | |
| SCHEMBL75552 | 0.80 | — | — | |
| SCHEMBL522543 | 0.78 | CRBN (0.40) | — | |
| SCHEMBL9579603 | 0.75 | — | — | |
| SCHEMBL896392 | 0.75 | — | — | |
| SCHEMBL9540689 | 0.73 | CRBN (0.36) | — | |
| SCHEMBL11635955 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0462884-B1 | TRH DERIVATIVES, THEIR PREPARATIONS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ADIR ET COMPAGNIE (FR) | 1993-06-16 | — | — | EP | claimed |
| US-5190923-A | For treatment of neurological disorders such as cognitive disorders | ADIR ET COMPAGNIE (FR) | 1993-03-02 | — | — | US | claimed |
| EP-0462884-A1 | TRH derivatives, their preparations and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1991-12-27 | — | — | EP | claimed |
| JP-4253995-A | — | — | None | — | — | JP | disclosed |
| EP-0912602-A4 | METHOD OF TREATING BETA-AMYLOID PEPTIDE ASSOCIATED CONDITIONS USING TRH | LILLY CO ELI (US) | 2002-09-11 | — | — | EP | disclosed |
| EP-0912602-A1 | METHOD OF TREATING BETA-AMYLOID PEPTIDE ASSOCIATED CONDITIONS USING TRH | ELI LILLY AND COMPANY (US) | 1999-05-06 | — | — | EP | disclosed |
| WO-1997028184-A1 | METHOD OF TREATING BETA-AMYLOID PEPTIDE ASSOCIATED CONDITIONS USING TRH | ELI LILLY AND COMPANY (US) | 1997-08-07 | — | — | WO | disclosed |
| EP-0462884-B1 | TRH DERIVATIVES, THEIR PREPARATIONS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ADIR ET COMPAGNIE (FR) | 1993-06-16 | — | — | EP | disclosed |
| US-5190923-A | For treatment of neurological disorders such as cognitive disorders | ADIR ET COMPAGNIE (FR) | 1993-03-02 | — | — | US | disclosed |
| JP-H04253995-A | NOVEL PEPTIDE COMPOUND | ADIR | 1992-09-09 | — | — | JP | disclosed |
| EP-0462884-A1 | TRH derivatives, their preparations and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1991-12-27 | — | — | EP | disclosed |