Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.45 |
| ▸ | CASP6 | P55212 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7445875 | 0.94 | SMN1; SMN2 (0.55) | MTNR1ASMN1; SMN2MAPTALDH1A1TSHR | |
| SCHEMBL22158332 | 0.90 | MTNR1A (0.55) | MTNR1ASMN1; SMN2MAPTALDH1A1TSHR | |
| SCHEMBL11483282 | 0.84 | SMN1; SMN2 (0.54) | MTNR1ASMN1; SMN2MAPTALDH1A1TSHR | |
| SCHEMBL11492391 | 0.82 | SMN1; SMN2 (0.53) | MTNR1ASMN1; SMN2MAPTALDH1A1TSHR | |
| SCHEMBL7436303 | 0.80 | RAB9A (0.50) | SMN1; SMN2MAPTALDH1A1NPC1RAB9A | |
| SCHEMBL17888023 | 0.79 | HPGD (0.50) | MTNR1ASMN1; SMN2MAPTALDH1A1TSHR | |
| SCHEMBL19750333 | 0.78 | MTNR1A (0.47) | MTNR1ASMN1; SMN2MAPTALDH1A1TSHR | |
| SCHEMBL1878665 | 0.78 | MTNR1A (0.51) | MTNR1ASMN1; SMN2MAPTALDH1A1TSHR | |
| SCHEMBL21198179 | 0.77 | NPC1 (0.52) | MTNR1ASMN1; SMN2MAPTALDH1A1TSHR | |
| SCHEMBL8121091 | 0.77 | MTNR1A (0.45) | MTNR1ASMN1; SMN2MAPTALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4558129-A | Benzodioxanyl-hydroxyethylene-piperazinyl acetanilides which effect calcium entry and β-blockade | SYNTEX (U.S.A.) INC. (US) | 1985-12-10 | — | — | US | disclosed |
| US-4499100-A | CARDIOUVASCULAR DISORDERS | SYNTEX (U.S.A.) INC. (US) | 1985-02-12 | — | — | US | disclosed |