Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.31 |
| ▸ | USP2 | O75604 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9242735 | 1.00 | ADRB2 (0.34) | ADRB2ADRB1ADRB3TDP1TSHR | |
| SCHEMBL4052324 | 0.80 | CYP1A2 (0.33) | LMNAALDH1A1 | |
| SCHEMBL10487647 | 0.79 | SMN1; SMN2 (0.40) | MAPTSMN1; SMN2 | |
| SCHEMBL1485424 | 0.78 | BTN3A1 (0.33) | ADRB2ADRB1ADRB3SMN1; SMN2 | |
| SCHEMBL32668778 | 0.78 | BTN3A1 (0.33) | ADRB2ADRB1ADRB3SMN1; SMN2 | |
| SCHEMBL1485422 | 0.78 | BTN3A1 (0.33) | ADRB2ADRB1ADRB3SMN1; SMN2 | |
| SCHEMBL13866361 | 0.76 | TDP1 (0.32) | ADRB2ADRB1ADRB3TDP1SMN1; SMN2 | |
| SCHEMBL5935161 | 0.74 | PGK1 (0.39) | SMN1; SMN2 | |
| SCHEMBL2343223 | 0.74 | — | — | |
| SCHEMBL2343220 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0535042-B1 | ANGIOTENSIS CONVERTING ENZYME INHIBITORS | FISONS PLC (GB) | 1995-03-29 | — | — | EP | disclosed |
| US-5348978-A | Angiotensin converting enzyme inhibitors | FISONS PLC (GB) | 1994-09-20 | — | — | US | disclosed |
| EP-0535042-A1 | ANGIOTENSIS CONVERTING ENZYME INHIBITORS. | FISONS PLC (GB) | 1993-04-07 | — | — | EP | disclosed |
| WO-1992000276-A2 | ANGIOTENSIS CONVERTING ENZYME INHIBITORS | FISONS PLC (GB) | 1992-01-09 | — | — | WO | disclosed |