Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | TYR | P14679 | 3/20 | 0.50 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.50 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.46 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25906319 | 0.90 | TRPA1 (0.55) | TRPA1PTGS1CACNA1CALDH1A1HTT | |
| SCHEMBL14252297 | 0.90 | TYR (0.48) | TRPA1PTGS1CACNA1CALDH1A1HTT | |
| SCHEMBL17707900 | 0.89 | TYR (0.50) | TRPA1PTGS1CACNA1CALDH1A1HTT | |
| SCHEMBL22888342 | 0.89 | PTGS1 (0.48) | TRPA1PTGS1CACNA1CALDH1A1HTT | |
| SCHEMBL4282140 | 0.88 | PTPN5 (0.57) | TRPA1PTGS1CACNA1CALDH1A1HTT | |
| SCHEMBL11651790 | 0.87 | TRPA1 (0.64) | TRPA1PTGS1CACNA1CALDH1A1HTT | |
| SCHEMBL23754720 | 0.86 | BACE1 (0.46) | TRPA1PTGS1CACNA1CALDH1A1HTT | |
| SCHEMBL25898933 | 0.85 | PTGS1 (0.57) | TRPA1PTGS1CACNA1CALDH1A1HTT | |
| SCHEMBL5951050 | 0.85 | TYR (0.44) | TRPA1PTGS1CACNA1CALDH1A1HTT | |
| SCHEMBL14877648 | 0.85 | TRPA1 (0.48) | TRPA1PTGS1CACNA1CALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183239-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | G.D. SEARLE & CO. (US) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000069821-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | G.D. SEARLE & CO. (US) | 2000-11-23 | — | — | WO | disclosed |