Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.45 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7442632 | 0.82 | MAPK1 (0.50) | MAPK1ALOX15RXFP1GAAMAPT | |
| SCHEMBL8899504 | 0.81 | MEN1 (0.44) | ALOX15RXFP1GAAMAPTMEN1 | |
| SCHEMBL7442172 | 0.78 | MEN1 (0.69) | MAPK1ALOX15RXFP1GAAMAPT | |
| SCHEMBL7167114 | 0.76 | MAPT (0.60) | MAPK1ALOX15RXFP1GAAMAPT | |
| SCHEMBL7160571 | 0.72 | MAPT (0.55) | MAPK1ALOX15GAAMAPTMEN1 | |
| SCHEMBL7160516 | 0.72 | KCNK3 (0.65) | MAPK1ALOX15GAAMAPTMEN1 | |
| SCHEMBL6332463 | 0.71 | MAPT (0.54) | MAPK1ALOX15RXFP1GAAMAPT | |
| SCHEMBL15528576 | 0.71 | MEN1 (0.67) | MAPK1ALOX15RXFP1GAAMAPT | |
| SCHEMBL988 | 0.70 | MAPT (0.50) | MAPK1ALOX15RXFP1GAAMAPT | |
| SCHEMBL7721826 | 0.70 | PTPN1 (0.58) | MAPK1RXFP1GAAMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6391885-B1 | CONTROLLING APOPTOSIS IN AUTOIMMUNE DISEASE | CELL PATHWAYS, INC. | 2002-05-21 | — | — | US | disclosed |
| US-6060477-A | Method of treating a patient having precancerous lesions with phenyl cycloamino pyrimidinone derivatives | CELL PATHWAYS, INC. (US) | 2000-05-09 | — | — | US | disclosed |
| EP-0656898-B1 | PYRIDOPYRIMIDINONE ANTIANGINAL AGENTS | PFIZER LTD (GB) | 1997-01-22 | — | — | EP | disclosed |
| US-5591742-A | TREATMENT OF ANGINA, HYPERTENSION, ATHEROSCLEROSIS, CARDIOVASCULAR DISORDERS | PFIZER INC. (US) | 1997-01-07 | — | — | US | disclosed |
| EP-0656898-A1 | PYRIDOPYRIMIDINONE ANTIANGINAL AGENTS. | PFIZER RES & DEV (IE) | 1995-06-14 | — | — | EP | disclosed |
| WO-1994005661-A1 | PYRIDOPYRIMIDINONE ANTIANGINAL AGENTS | PFIZER LIMITED (GB) | 1994-03-17 | — | — | WO | disclosed |