Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | PLEC | Q15149 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7435773 | 0.81 | MAPK1 (0.49) | MEN1KMT2AALDH1A1GAAL3MBTL1 | |
| SCHEMBL29941277 | 0.68 | MKNK1 (0.48) | MEN1KMT2AALDH1A1GAAL3MBTL1 | |
| SCHEMBL6305012 | 0.68 | MKNK1 (0.48) | MEN1KMT2AALDH1A1GAAL3MBTL1 | |
| SCHEMBL7442632 | 0.67 | MAPK1 (0.50) | MEN1KMT2AALDH1A1GAAL3MBTL1 | |
| SCHEMBL11547887 | 0.65 | KDM4E (0.51) | MEN1KMT2AALDH1A1L3MBTL1MAPT | |
| SCHEMBL22261304 | 0.65 | JAK3 (0.62) | MEN1KMT2ATHRBALDH1A1GAA | |
| SCHEMBL27569268 | 0.65 | L3MBTL1 (0.47) | MEN1KMT2AALDH1A1GAAL3MBTL1 | |
| SCHEMBL28847591 | 0.65 | MEN1 (0.49) | MEN1KMT2AALDH1A1L3MBTL1MAPT | |
| SCHEMBL10321813 | 0.65 | MYC (0.39) | KMT2AGAARECQLATMKDM4E | |
| SCHEMBL4011789 | 0.65 | L3MBTL1 (0.58) | MEN1KMT2ATHRBALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5591742-A | TREATMENT OF ANGINA, HYPERTENSION, ATHEROSCLEROSIS, CARDIOVASCULAR DISORDERS | PFIZER INC. (US) | 1997-01-07 | — | — | US | disclosed |