Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 6/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 6/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 6/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19018643 | 0.80 | GAA (0.51) | POLBTDP1GAAALDH1A1KDM4E | |
| SCHEMBL9576486 | 0.77 | SMN1; SMN2 (0.46) | TDP1GAAALDH1A1KDM4EKMT2A | |
| SCHEMBL9576447 | 0.75 | SMN1; SMN2 (0.45) | POLBTDP1GAAALDH1A1KMT2A | |
| SCHEMBL13847664 | 0.73 | NPSR1 (0.45) | POLBTDP1GAAALDH1A1KDM4E | |
| SCHEMBL15185777 | 0.73 | KDM4E (0.43) | GABRG2GABRB3GABRA2GABRA5GABRA3 | |
| SCHEMBL3536595 | 0.72 | GAA (0.37) | POLBTDP1GAAMAPTL3MBTL1 | |
| SCHEMBL13176680 | 0.72 | — | — | |
| SCHEMBL3258892 | 0.72 | GDA (0.43) | POLBTDP1GAAALDH1A1KDM4E | |
| SCHEMBL1560676 | 0.72 | GDA (0.41) | POLBTDP1GAAALDH1A1KDM4E | |
| SCHEMBL311900 | 0.71 | KDM4E (0.64) | POLBGAAALDH1A1KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0647227-A1 | PURINONE ANTIANGINAL AGENTS. | PFIZER LTD (GB) | 1995-04-12 | — | — | EP | disclosed |
| WO-1994000453-A1 | PURINONE ANTIANGINAL AGENTS | PFIZER LIMITED (GB) | 1994-01-06 | — | — | WO | disclosed |