Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28431266 | 0.90 | SMN1; SMN2 (0.47) | POLBKMT2ACYP1A2CHRM2CYP2D6 | |
| SCHEMBL7435972 | 0.89 | HTR2A (0.42) | POLBHTR2AHTR2CKMT2ACYP1A2 | |
| SCHEMBL7430490 | 0.85 | POLB (0.41) | POLBKMT2ACYP1A2CHRM2CYP2D6 | |
| SCHEMBL28430986 | 0.85 | POLB (0.53) | POLBKMT2ACYP1A2CHRM2CYP2D6 | |
| SCHEMBL5552878 | 0.81 | POLB (0.50) | POLBKMT2ACYP1A2CHRM2CYP2D6 | |
| SCHEMBL7435421 | 0.78 | POLB (0.40) | POLBKMT2ACYP1A2CHRM2CYP2D6 | |
| SCHEMBL9545140 | 0.74 | POLB (0.51) | POLBKMT2ACYP1A2CHRM2CYP2D6 | |
| Hydrochloric Acid SCHEMBL9241189 | 0.73 | POLB (0.50) | POLBKMT2ACYP1A2CHRM2CYP2D6 | |
| SCHEMBL2761350 | 0.71 | KMT2A (0.50) | KMT2ALMNAMEN1ALDH1A1MAPK1 | |
| SCHEMBL28438106 | 0.70 | L3MBTL1 (0.49) | POLBKMT2ACYP1A2CHRM2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5891899-A | Pharmaceutical xanthene compounds | ELI LILLY AND COMPANY LIMITED (GB) | 1999-04-06 | — | — | US | disclosed |
| EP-0849263-A2 | Pharmaceutical substituted propanoic acid derivatives | ELI LILLY AND COMPANY LIMITED (GB) | 1998-06-24 | — | — | EP | disclosed |