Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 16/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | PDE6C | P51160 | 3/20 | 0.46 |
| ▸ | PDE1A | P54750 | 4/20 | 0.44 |
| ▸ | PDE1B | Q01064 | 4/20 | 0.44 |
| ▸ | PDE1C | Q14123 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.42 |
| ▸ | PDE2A | O00408 | 2/20 | 0.42 |
| ▸ | PDE6D | O43924 | 2/20 | 0.42 |
| ▸ | PDE9A | O76083 | 2/20 | 0.42 |
| ▸ | PDE6A | P16499 | 2/20 | 0.42 |
| ▸ | PDE6G | P18545 | 2/20 | 0.42 |
| ▸ | PDE4A | P27815 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7440676 | 0.85 | PDE5A (0.66) | PDE5AKMT2APDE6CPDE1APDE1B | |
| SCHEMBL7444361 | 0.84 | PDE5A (0.49) | PDE5AKMT2APDE6CPDE1APDE1B | |
| SCHEMBL7721206 | 0.82 | KDM4E (0.66) | PDE5AKMT2APDE6CPDE1APDE1B | |
| SCHEMBL6641368 | 0.81 | PDE5A (0.61) | PDE5AKMT2APDE6CPDE1APDE1B | |
| SCHEMBL7432093 | 0.81 | GUSB (0.53) | PDE5AKMT2APDE1APDE1BPDE1C | |
| SCHEMBL7721655 | 0.80 | PDE5A (0.47) | PDE5AKMT2APDE6CPDE1APDE1B | |
| SCHEMBL8149898 | 0.78 | PDE5A (0.70) | PDE5APDE6CPDE1APDE1BPDE1C | |
| SCHEMBL7721640 | 0.78 | PDE5A (0.69) | PDE5APDE6CPDE1APDE1BPDE1C | |
| SCHEMBL7950435 | 0.77 | KMT2A (0.77) | PDE5AKMT2APDE6CPDE1APDE1B | |
| SCHEMBL7718300 | 0.76 | ABCC5 (0.47) | PDE5AKMT2APDE6CPDE1AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6391885-B1 | CONTROLLING APOPTOSIS IN AUTOIMMUNE DISEASE | CELL PATHWAYS, INC. | 2002-05-21 | — | — | US | disclosed |
| US-6060477-A | Method of treating a patient having precancerous lesions with phenyl cycloamino pyrimidinone derivatives | CELL PATHWAYS, INC. (US) | 2000-05-09 | — | — | US | disclosed |
| EP-0656898-B1 | PYRIDOPYRIMIDINONE ANTIANGINAL AGENTS | PFIZER LTD (GB) | 1997-01-22 | — | — | EP | disclosed |
| US-5591742-A | TREATMENT OF ANGINA, HYPERTENSION, ATHEROSCLEROSIS, CARDIOVASCULAR DISORDERS | PFIZER INC. (US) | 1997-01-07 | — | — | US | disclosed |
| EP-0656898-A1 | PYRIDOPYRIMIDINONE ANTIANGINAL AGENTS. | PFIZER RES & DEV (IE) | 1995-06-14 | — | — | EP | disclosed |
| WO-1994005661-A1 | PYRIDOPYRIMIDINONE ANTIANGINAL AGENTS | PFIZER LIMITED (GB) | 1994-03-17 | — | — | WO | disclosed |