Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | PDE5A | O76074 | 16/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | PDE2A | O00408 | 2/20 | 0.50 |
| ▸ | PDE9A | O76083 | 2/20 | 0.50 |
| ▸ | PDE4A | P27815 | 2/20 | 0.50 |
| ▸ | PDE6C | P51160 | 2/20 | 0.50 |
| ▸ | PDE1A | P54750 | 2/20 | 0.50 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.49 |
| ▸ | ABCC5 | O15440 | 2/20 | 0.47 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.47 |
| ▸ | PDE6D | O43924 | 1/20 | 0.47 |
| ▸ | PDE8A | O60658 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8801494 | 0.83 | PDE5A (0.58) | KDM4EPDE5APDE2APDE9APDE4A | |
| SCHEMBL8149898 | 0.83 | PDE5A (0.70) | PDE5APDE2APDE9APDE4APDE6C | |
| SCHEMBL7721640 | 0.83 | PDE5A (0.69) | PDE5APDE2APDE9APDE4APDE6C | |
| SCHEMBL7721903 | 0.82 | PDE5A (0.73) | KDM4EPDE5APDE2APDE9APDE4A | |
| SCHEMBL7435920 | 0.82 | PDE5A (0.51) | KDM4EPDE5AKMT2APDE2APDE9A | |
| SCHEMBL7444361 | 0.81 | PDE5A (0.49) | KDM4EPDE5AKMT2APDE2APDE9A | |
| SCHEMBL7721655 | 0.81 | PDE5A (0.47) | KDM4EPDE5AKMT2APDE2APDE9A | |
| SCHEMBL7718300 | 0.81 | ABCC5 (0.47) | KDM4EPDE5AKMT2APDE2APDE9A | |
| SCHEMBL7440676 | 0.80 | PDE5A (0.66) | KDM4EPDE5AKMT2APDE2APDE9A | |
| SCHEMBL3840503 | 0.79 | PDE5A (0.72) | PDE5APDE2APDE9APDE4APDE6C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6391885-B1 | CONTROLLING APOPTOSIS IN AUTOIMMUNE DISEASE | CELL PATHWAYS, INC. | 2002-05-21 | — | — | US | disclosed |
| US-6060477-A | Method of treating a patient having precancerous lesions with phenyl cycloamino pyrimidinone derivatives | CELL PATHWAYS, INC. (US) | 2000-05-09 | — | — | US | disclosed |
| EP-0656898-B1 | PYRIDOPYRIMIDINONE ANTIANGINAL AGENTS | PFIZER LTD (GB) | 1997-01-22 | — | — | EP | disclosed |
| US-5591742-A | TREATMENT OF ANGINA, HYPERTENSION, ATHEROSCLEROSIS, CARDIOVASCULAR DISORDERS | PFIZER INC. (US) | 1997-01-07 | — | — | US | disclosed |