Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 19/20 | 0.69 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.59 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.59 |
| ▸ | PDE1A | P54750 | 3/20 | 0.59 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.59 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.59 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.59 |
| ▸ | PDE2A | O00408 | 1/20 | 0.59 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.59 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.59 |
| ▸ | PDE6D | O43924 | 1/20 | 0.59 |
| ▸ | PDE8A | O60658 | 1/20 | 0.59 |
| ▸ | PDE9A | O76083 | 1/20 | 0.59 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | HTR1A | P08908 | 1/20 | 0.59 |
| ▸ | PDE6A | P16499 | 1/20 | 0.59 |
| ▸ | PDE6G | P18545 | 1/20 | 0.59 |
| ▸ | PDE4A | P27815 | 1/20 | 0.59 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8149898 | 0.92 | PDE5A (0.70) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL3840503 | 0.88 | PDE5A (0.72) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL3842010 | 0.87 | PDE5A (0.63) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL5596744 | 0.86 | PDE5A (0.62) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL7725915 | 0.86 | PDE5A (0.62) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL7721206 | 0.83 | KDM4E (0.66) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL1141 | 0.82 | PDE5A (1.00) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL30199797 | 0.82 | PDE5A (1.00) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL8801494 | 0.80 | PDE5A (0.58) | PDE5APDE1APDE2APDE9APDE4A | |
| SCHEMBL9021637 | 0.80 | PDE5A (0.86) | PDE5APDE3BPDE3APDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6391885-B1 | CONTROLLING APOPTOSIS IN AUTOIMMUNE DISEASE | CELL PATHWAYS, INC. | 2002-05-21 | — | — | US | disclosed |
| US-6060477-A | Method of treating a patient having precancerous lesions with phenyl cycloamino pyrimidinone derivatives | CELL PATHWAYS, INC. (US) | 2000-05-09 | — | — | US | disclosed |
| EP-0656898-B1 | PYRIDOPYRIMIDINONE ANTIANGINAL AGENTS | PFIZER LTD (GB) | 1997-01-22 | — | — | EP | disclosed |
| US-5591742-A | TREATMENT OF ANGINA, HYPERTENSION, ATHEROSCLEROSIS, CARDIOVASCULAR DISORDERS | PFIZER INC. (US) | 1997-01-07 | — | — | US | disclosed |