Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 4/20 | 0.46 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 3/20 | 0.41 |
| ▸ | CCND2 | P30279 | 1/20 | 0.41 |
| ▸ | CCND3 | P30281 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PDE9A | O76083 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31403565 | 0.85 | CDK4 (0.41) | CDK4CDK6ALDH1A1MAPK1CCND1 | |
| SCHEMBL31403524 | 0.78 | HCAR3 (0.43) | CDK4CDK6CCND1PDE9AAURKA | |
| SCHEMBL1355934 | 0.76 | AURKA (0.58) | CDK4CDK6CCND1CCND3CYP2C9 | |
| SCHEMBL12498824 | 0.74 | EZH2 (0.57) | CDK4ALDH1A1PDE4BMAPTCCND1 | |
| SCHEMBL574443 | 0.73 | LMNA (0.53) | ALDH1A1MAPK1PDE4BMAPTPOLB | |
| SCHEMBL12498746 | 0.73 | EZH2 (0.56) | ALDH1A1PDE4BMAPTPDE9ANPSR1 | |
| SCHEMBL30984286 | 0.72 | LMNA (0.52) | ALDH1A1MAPK1PDE4BMAPTPOLB | |
| SCHEMBL13848928 | 0.72 | LMNA (0.55) | ALDH1A1MAPK1PDE4BMAPTPDE7A | |
| SCHEMBL12499903 | 0.71 | EZH2 (0.55) | CDK4PDE4BCCND1CCND2CCND3 | |
| SCHEMBL1406792 | 0.71 | LMNA (0.51) | ALDH1A1MAPK1PDE4BMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0355234-A1 | Pyrazolopyridine derivatives as antiatherosclerotic and antihypercholesterolemic agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-02-28 | — | — | EP | disclosed |