Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 11/20 | 0.47 |
| ▸ | EDNRA | P25101 | 11/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.45 |
| ▸ | TACR1 | P25103 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16907005 | 1.00 | EDNRB (0.47) | EDNRBEDNRAALDH1A1MAPTHDAC1 | |
| SCHEMBL7436226 | 1.00 | EDNRB (0.47) | EDNRBEDNRAALDH1A1MAPTHDAC1 | |
| SCHEMBL8724866 | 0.93 | TACR1 (0.45) | EDNRBEDNRAALDH1A1MAPTTACR1 | |
| SCHEMBL8724868 | 0.93 | TACR1 (0.45) | EDNRBEDNRAALDH1A1MAPTTACR1 | |
| SCHEMBL8726256 | 0.89 | NPY5R (0.46) | EDNRBEDNRA | |
| SCHEMBL8726260 | 0.89 | NPY5R (0.46) | EDNRBEDNRA | |
| SCHEMBL7451075 | 0.88 | ALDH1A1 (0.50) | EDNRBEDNRAALDH1A1MAPT | |
| SCHEMBL16907004 | 0.88 | ALDH1A1 (0.50) | EDNRBEDNRAALDH1A1MAPT | |
| SCHEMBL7451078 | 0.88 | ALDH1A1 (0.50) | EDNRBEDNRAALDH1A1MAPT | |
| SCHEMBL8490486 | 0.87 | SLC7A5 (0.40) | EDNRBEDNRAHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977075-A | N-aroylamino acid amides as endothelin inhibitors | NOVARTIS AG (CH) | 1999-11-02 | — | — | US | disclosed |
| EP-0821670-A1 | N-AROYLAMINO ACID AMIDES AS ENDOTHELIN INHIBITORS | Novartis AG (CH) | 1998-02-04 | — | — | EP | disclosed |
| US-5703106-A | TREATING VARIOUS CARDIOVASCULAR, UROGENITAL, BRAIN DISORDERS | JAPAT LTD. (CH) | 1997-12-30 | — | — | US | disclosed |
| EP-0753004-A1 | ANTAGONISTS OF ENDOTHELIN RECEPTORS | Japat Ltd (CH) | 1997-01-15 | — | — | EP | disclosed |
| WO-1996033170-A1 | N-AROYLAMINO ACID AMIDES AS ENDOTHELIN INHIBITORS | NOVARITS AG (CH) | 1996-10-24 | — | — | WO | disclosed |
| WO-1995026360-A1 | ANTAGONISTS OF ENDOTHELIN RECEPTORS | JAPAT LTD. (CH) | 1995-10-05 | — | — | WO | disclosed |