Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.40 |
| ▸ | EDNRB | P24530 | 11/20 | 0.39 |
| ▸ | EDNRA | P25101 | 11/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8490484 | 1.00 | SLC7A5 (0.40) | SLC7A5EDNRBEDNRATAS1R3TAS1R1 | |
| SCHEMBL8721883 | 0.90 | ESR1 (0.47) | EDNRBEDNRATAS1R3TAS1R1LNPEP | |
| SCHEMBL8721886 | 0.90 | ESR1 (0.47) | EDNRBEDNRATAS1R3TAS1R1LNPEP | |
| SCHEMBL8724866 | 0.89 | TACR1 (0.45) | EDNRBEDNRAABCB1BACE1BACE2 | |
| SCHEMBL8724868 | 0.89 | TACR1 (0.45) | EDNRBEDNRAABCB1BACE1BACE2 | |
| SCHEMBL7436226 | 0.87 | EDNRB (0.47) | EDNRBEDNRAHDAC1HDAC6 | |
| SCHEMBL16907005 | 0.87 | EDNRB (0.47) | EDNRBEDNRAHDAC1HDAC6 | |
| SCHEMBL7436229 | 0.87 | EDNRB (0.47) | EDNRBEDNRAHDAC1HDAC6 | |
| SCHEMBL8726256 | 0.85 | NPY5R (0.46) | EDNRBEDNRA | |
| SCHEMBL8489138 | 0.85 | LMNA (0.41) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977075-A | N-aroylamino acid amides as endothelin inhibitors | NOVARTIS AG (CH) | 1999-11-02 | — | — | US | disclosed |
| EP-0821670-A1 | N-AROYLAMINO ACID AMIDES AS ENDOTHELIN INHIBITORS | Novartis AG (CH) | 1998-02-04 | — | — | EP | disclosed |
| WO-1996033170-A1 | N-AROYLAMINO ACID AMIDES AS ENDOTHELIN INHIBITORS | NOVARITS AG (CH) | 1996-10-24 | — | — | WO | disclosed |