Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 10/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.36 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7423576 | 0.84 | REN (0.42) | RENBCHEPSEN1PSEN2APH1B | |
| SCHEMBL7436333 | 0.81 | REN (0.46) | RENBCHEPSEN1PSEN2APH1B | |
| SCHEMBL7441467 | 0.80 | BCHE (0.41) | RENBCHEPSEN1PSEN2APH1B | |
| SCHEMBL7440602 | 0.79 | REN (0.39) | RENBCHEPSEN1PSEN2APH1B | |
| SCHEMBL7429694 | 0.78 | REN (0.38) | RENBCHEPSEN1PSEN2APH1B | |
| SCHEMBL7281059 | 0.76 | REN (0.66) | RENBCHE | |
| SCHEMBL7424258 | 0.74 | CCR1 (0.40) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL13707910 | 0.72 | CTSK (0.44) | — | |
| SCHEMBL18435239 | 0.72 | CTSK (0.44) | — | |
| SCHEMBL13707911 | 0.72 | CTSK (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0296581-A2 | Amino acid 1,2-diketo derivatives as renin inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1988-12-28 | — | — | EP | disclosed |