Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 20/20 | 0.73 |
| ▸ | HTR1A | P08908 | 3/20 | 0.55 |
| ▸ | HTR1D | P28221 | 3/20 | 0.55 |
| ▸ | HTR1B | P28222 | 3/20 | 0.55 |
| ▸ | HTR1F | P30939 | 3/20 | 0.55 |
| ▸ | HTR7 | P34969 | 3/20 | 0.55 |
| ▸ | DRD3 | P35462 | 3/20 | 0.55 |
| ▸ | DRD2 | P14416 | 2/20 | 0.52 |
| ▸ | HTR1E | P28566 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5504710 | 0.84 | HTR6 (1.00) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL1357126 | 0.84 | HTR6 (1.00) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| Hydrochloric Acid SCHEMBL7320940 | 0.84 | HTR6 (0.70) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| Oxalic Acid SCHEMBL7433702 | 0.82 | HTR6 (0.90) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL5500213 | 0.82 | HTR6 (0.74) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL5502012 | 0.82 | HTR6 (1.00) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL7023756 | 0.82 | HTR6 (0.68) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| Hydrochloric Acid SCHEMBL7438828 | 0.81 | HTR6 (0.98) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| Oxalic Acid SCHEMBL7436726 | 0.81 | HTR6 (0.69) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL7313610 | 0.81 | HTR6 (0.62) | HTR6HTR1AHTR1DHTR1BHTR1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187805-B1 | TREATING CONDITION FOR WHICH SELECTIVE AGONISM OR ANTAGONISM OF 5-HT-6 RECEPTORS IS INDICATED BY ADMINISTERING COMPOUNDS SUCH AS N,N-DIMETHYL 2-(1-(BENZENESULPHONYL)-5-METHOXY-1H-INDOL-3-YL)ETHYLAMINE | MERCK SHARP & DOHME LTD. (GB) | 2001-02-13 | — | — | US | disclosed |