Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 16/20 | 1.00 |
| ▸ | DRD3 | P35462 | 15/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 11/20 | 1.00 |
| ▸ | DRD4 | P21917 | 7/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.83 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.83 |
| ▸ | HTR1A | P08908 | 5/20 | 0.75 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.75 |
| ▸ | DRD1 | P21728 | 2/20 | 0.75 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.75 |
| ▸ | HTR2A | P28223 | 2/20 | 0.75 |
| ▸ | HTR2C | P28335 | 2/20 | 0.75 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.75 |
| ▸ | HTR2B | P41595 | 2/20 | 0.75 |
| ▸ | MEN1 | O00255 | 1/20 | 0.75 |
| ▸ | LMNA | P02545 | 1/20 | 0.75 |
| ▸ | TP53 | P04637 | 1/20 | 0.75 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.75 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7594688 | 0.96 | DRD2 (0.92) | DRD2DRD3ADRA1ADRD4SLC6A4 | |
| SCHEMBL8183795 | 0.91 | DRD3 (0.94) | DRD2DRD3ADRA1ADRD4SLC6A4 | |
| Hydrochloric Acid SCHEMBL7533065 | 0.90 | DRD3 (0.93) | DRD2DRD3ADRA1ADRD4SLC6A4 | |
| Hydrochloric Acid SCHEMBL7539738 | 0.89 | DRD2 (0.79) | DRD2DRD3ADRA1ADRD4SLC6A4 | |
| Hydrochloric Acid SCHEMBL7532020 | 0.89 | DRD2 (0.79) | DRD2DRD3ADRA1ADRD4SLC6A4 | |
| SCHEMBL7526939 | 0.87 | DRD3 (0.77) | DRD2DRD3ADRA1ADRD4SLC6A4 | |
| SCHEMBL7343763 | 0.87 | DRD3 (0.89) | DRD2DRD3ADRA1ADRD4SLC6A4 | |
| SCHEMBL7438237 | 0.86 | DRD3 (1.00) | DRD2DRD3ADRA1ADRD4SLC6A4 | |
| Bp-897 SCHEMBL2125882 | 0.86 | DRD2 (1.00) | DRD2DRD3ADRA1ADRD4SLC6A4 | |
| Bp-897 SCHEMBL29382551 | 0.86 | DRD2 (1.00) | DRD2DRD3ADRA1ADRD4SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779284-B1 | Novel 2-naphthamide derivatives and their use in therapy as D3 receptor agonists | INST NAT SANTE RECH MED (FR) | 2002-07-10 | — | — | EP | claimed |
| US-5872119-A | 2-Naphthamide derivatives and their therapeutic applications | Institut National De La Sante et De La Recherche Medicale--INSERM (FR) | 1999-02-16 | — | — | US | claimed |
| EP-0779284-A1 | Novel 2-naphthamide derivatives and their use in therapy as D3 receptor agonists | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1997-06-18 | — | — | EP | claimed |
| EP-0779284-B1 | Novel 2-naphthamide derivatives and their use in therapy as D3 receptor agonists | INST NAT SANTE RECH MED (FR) | 2002-07-10 | — | — | EP | disclosed |
| US-5985895-A | 2-naphthamide derivatives and their therapeutic applications | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE-INSERM (FR) | 1999-11-16 | — | — | US | disclosed |
| US-5872119-A | 2-Naphthamide derivatives and their therapeutic applications | Institut National De La Sante et De La Recherche Medicale--INSERM (FR) | 1999-02-16 | — | — | US | disclosed |
| EP-0779284-A1 | Novel 2-naphthamide derivatives and their use in therapy as D3 receptor agonists | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1997-06-18 | — | — | EP | disclosed |