Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 14/20 | 1.00 |
| ▸ | DRD2 | P14416 | 12/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 12/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.79 |
| ▸ | DRD4 | P21917 | 2/20 | 0.76 |
| ▸ | HTR1A | P08908 | 2/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.71 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7432969 | 0.91 | DRD3 (1.00) | DRD3DRD2ADRA1ASLC6A4DRD4 | |
| SCHEMBL7436346 | 0.86 | DRD2 (1.00) | DRD3DRD2ADRA1ASLC6A4DRD4 | |
| SCHEMBL10724572 | 0.84 | DRD3 (0.78) | DRD3DRD2ADRA1ASLC6A4DRD4 | |
| SCHEMBL27880047 | 0.83 | DRD2 (0.81) | DRD3DRD2ADRA1ASLC6A4DRD4 | |
| SCHEMBL4529984 | 0.83 | DRD3 (1.00) | DRD3DRD2ADRA1AHTR1AKCNH2 | |
| Hydrochloric Acid SCHEMBL7594688 | 0.82 | DRD2 (0.92) | DRD3DRD2ADRA1ASLC6A4DRD4 | |
| SCHEMBL8183795 | 0.82 | DRD3 (0.94) | DRD3DRD2ADRA1ASLC6A4DRD4 | |
| Hydrochloric Acid SCHEMBL7533065 | 0.81 | DRD3 (0.93) | DRD3DRD2ADRA1ASLC6A4DRD4 | |
| SCHEMBL7392912 | 0.81 | DRD3 (0.73) | DRD3DRD2ADRA1ASLC6A4DRD4 | |
| SCHEMBL5651142 | 0.80 | DRD3 (0.66) | DRD3DRD2ADRA1ASLC6A4DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779284-B1 | Novel 2-naphthamide derivatives and their use in therapy as D3 receptor agonists | INST NAT SANTE RECH MED (FR) | 2002-07-10 | — | — | EP | claimed |
| US-5872119-A | 2-Naphthamide derivatives and their therapeutic applications | Institut National De La Sante et De La Recherche Medicale--INSERM (FR) | 1999-02-16 | — | — | US | claimed |
| EP-0779284-A1 | Novel 2-naphthamide derivatives and their use in therapy as D3 receptor agonists | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1997-06-18 | — | — | EP | claimed |
| EP-0779284-B1 | Novel 2-naphthamide derivatives and their use in therapy as D3 receptor agonists | INST NAT SANTE RECH MED (FR) | 2002-07-10 | — | — | EP | disclosed |
| US-5985895-A | 2-naphthamide derivatives and their therapeutic applications | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE-INSERM (FR) | 1999-11-16 | — | — | US | disclosed |
| US-5872119-A | 2-Naphthamide derivatives and their therapeutic applications | Institut National De La Sante et De La Recherche Medicale--INSERM (FR) | 1999-02-16 | — | — | US | disclosed |
| EP-0779284-A1 | Novel 2-naphthamide derivatives and their use in therapy as D3 receptor agonists | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1997-06-18 | — | — | EP | disclosed |