Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 1/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7438458 | 0.81 | CYP4F2 (0.36) | CYP4F2CYP4A11 | |
| SCHEMBL17617116 | 0.79 | CYP4F2 (0.42) | CYP4F2CYP4A11ALDH1A1MAPTTSHR | |
| SCHEMBL2477744 | 0.78 | CYP4F2 (0.39) | CYP4F2CYP4A11ALDH1A1TSHR | |
| SCHEMBL5000217 | 0.76 | CYP4F2 (0.39) | CYP4F2CYP4A11ALDH1A1TSHR | |
| SCHEMBL2204111 | 0.76 | CYP4F2 (0.39) | CYP4F2CYP4A11ALDH1A1TSHR | |
| SCHEMBL7438466 | 0.76 | — | — | |
| SCHEMBL28936386 | 0.75 | CYP4F2 (0.48) | CYP4F2CYP4A11ALDH1A1MAPT | |
| SCHEMBL27359921 | 0.75 | DGAT1 (0.35) | CYP4F2CYP4A11 | |
| SCHEMBL26828304 | 0.75 | CYP4F2 (0.40) | CYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL3183165 | 0.75 | DGAT1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6066666-A | OPTIONALLY N-SUBSTITUTED 3-MONO- AND DI-SUBSTITUTED 2-PYRROLIDINONES AND THIOLACTAM ANALOGS; TREAT SEIZURES, ANXIETY, AND ENHANCING 4-AMINOBUTYRIC ACID (GABA)-INDUCED CHLORIDE CURRENTS AT GABA RECEPTOR/IONOPHORE COMPLEX | WASHINGTON UNIVERSITY (US) | 2000-05-23 | — | — | US | disclosed |
| US-5776959-A | Anticonvulsant and anxiolytic lactam and thiolactam derivatives | WASHINGTON UNIVERSITY (US) | 1998-07-07 | — | — | US | disclosed |