Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | PDE4A | P27815 | 7/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.46 |
| ▸ | EGFR | P00533 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9787217 | 0.84 | LMNA (0.47) | LMNASMN1; SMN2EGFRCYP1A2CYP2C9 | |
| SCHEMBL7431462 | 0.82 | PDE3B (0.56) | LMNASMN1; SMN2PDE4APDE4BPDE4C | |
| SCHEMBL11185607 | 0.79 | PDE4A (0.48) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5537356 | 0.77 | LMNA (0.49) | LMNASMN1; SMN2EGFRL3MBTL1ALDH1A1 | |
| SCHEMBL950218 | 0.76 | LMNA (0.73) | LMNASMN1; SMN2EGFRCYP1A2CYP2C9 | |
| SCHEMBL7349147 | 0.72 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DCYP1A2 | |
| SCHEMBL5539360 | 0.72 | SMN1; SMN2 (0.62) | LMNASMN1; SMN2EGFRCYP1A2CYP2C9 | |
| SCHEMBL5531213 | 0.70 | SMN1; SMN2 (0.47) | LMNASMN1; SMN2EGFRHPGDATM | |
| SCHEMBL5537699 | 0.70 | POLB (0.47) | LMNASMN1; SMN2CYP1A2CYP2C9TSHR | |
| SCHEMBL7430671 | 0.70 | PDE3B (0.67) | LMNAPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4405628-A | 4-Pyridylimidazolones and method of use | MERRELL DOW PHARMACEUTICALS INC. (US) | 1983-09-20 | — | — | US | disclosed |