Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.47 |
| ▸ | F7 | P08709 | 1/20 | 0.46 |
| ▸ | F3 | P13726 | 1/20 | 0.46 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.46 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.46 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.46 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9787353 | 0.83 | MAP2K1 (0.52) | MAP2K1ALDH1A1APPGAAHCAR3 | |
| SCHEMBL7437748 | 0.80 | PDE3B (0.46) | ALDH1A1GAALMNACYP1A2CYP3A4 | |
| SCHEMBL7487387 | 0.80 | ALDH1A1 (0.48) | ALDH1A1GAAHDAC6CYP1A2CYP3A4 | |
| SCHEMBL9312864 | 0.76 | MAP2K1 (0.54) | MAP2K1ALDH1A1APPGAAHCAR3 | |
| SCHEMBL1141370 | 0.76 | MAP2K1 (0.54) | MAP2K1ALDH1A1APPGAAHCAR3 | |
| SCHEMBL29915528 | 0.75 | ALDH1A1 (0.71) | MAP2K1ALDH1A1APPGAAHCAR3 | |
| SCHEMBL1242243 | 0.75 | ALDH1A1 (0.71) | MAP2K1ALDH1A1APPGAAHCAR3 | |
| SCHEMBL9786683 | 0.75 | NAMPT (0.59) | ALDH1A1GAALMNAHIF1AHPGD | |
| Hydrochloric Acid SCHEMBL27841975 | 0.73 | ALDH1A1 (0.68) | MAP2K1ALDH1A1APPGAAHCAR3 | |
| Thymine SCHEMBL19057050 | 0.72 | F7 (0.58) | ALDH1A1APPGAAHCAR3HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0170214-B1 | THE PREPARATION OF 1,3-DIHYDRO-4-PYRIDOYL-2H-IMIDAZOL-2-ONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-09-13 | — | — | EP | disclosed |
| EP-0170214-A1 | The preparation of 1,3-Dihydro-4-pyridoyl-2H-imidazol-2-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-02-05 | — | — | EP | disclosed |
| US-4405628-A | 4-Pyridylimidazolones and method of use | MERRELL DOW PHARMACEUTICALS INC. (US) | 1983-09-20 | — | — | US | disclosed |
| EP-0059948-A1 | Novel aroylimidazolones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-09-15 | — | — | EP | disclosed |