Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10924690 | 0.81 | HTT (0.39) | TDP1MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL7437748 | 0.81 | PDE3B (0.46) | ALDH1A1L3MBTL1MEN1KMT2ACYP1A2 | |
| SCHEMBL10920111 | 0.80 | PBRM1 (0.53) | ALDH1A1MEN1KMT2ANPC1SMN1; SMN2 | |
| SCHEMBL7436776 | 0.80 | MAP2K1 (0.54) | ALDH1A1TDP1CYP1A2GAAHPGD | |
| SCHEMBL9787169 | 0.79 | ALDH1A1 (0.46) | ALDH1A1ATMTDP1L3MBTL1SRD5A2 | |
| SCHEMBL2135245 | 0.74 | — | — | |
| Acetic Acid SCHEMBL10976963 | 0.74 | SMN1; SMN2 (0.45) | ALDH1A1TDP1MEN1KMT2ARAB9A | |
| SCHEMBL7435134 | 0.74 | KMT2A (0.50) | ALDH1A1L3MBTL1MEN1KMT2ARAB9A | |
| SCHEMBL17261572 | 0.72 | MMP1 (0.53) | ALDH1A1ATMTDP1L3MBTL1SRD5A2 | |
| SCHEMBL7490028 | 0.72 | HPGDS (0.47) | ALDH1A1TDP1L3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3131545-B1 | USE OF ENOXIMONE IN THE TREATMENT OF ATOPIC IMMUNE-RELATED DISORDERS, IN PHARMACEUTICAL COMPOSITIONS AS WELL AS IN PHARMACEUTICAL PREPARATIONS | BREAKTHROUGH MEDICAL RES B V (NL) | 2024-05-29 | — | — | EP | disclosed |
| US-20230270724-A1 | PDE3 inhibitors for treating viral infections | BREAKTHROUGH MEDICAL RESEARCH B.V. (NL) | 2023-08-31 | — | — | US | disclosed |
| CN-116171151-A | PDE3 inhibitors for the treatment of viral infections | 突破医学研究公司 | 2023-05-26 | — | — | CN | disclosed |
| EP-4181887-A1 | PDE3 INHIBITORS FOR TREATING VIRAL INFECTIONS | Breakthrough Medical Research B.V. (NL) | 2023-05-24 | — | — | EP | disclosed |
| WO-2022018085-A1 | PDE3 INHIBITORS FOR TREATING VIRAL INFECTIONS | BREAKTHROUGH MEDICAL RESEARCH B.V. (NL) | 2022-01-27 | — | — | WO | disclosed |
| EP-3763365-A1 | AROYLIMIDAZOLONES FOR THE TREATMENT OF THAUMETOPOEA EXPOSURE | Breakthrough Medical Research B.V. (NL) | 2021-01-13 | — | — | EP | disclosed |
| US-10071077-B2 | Use of enoximone in the treatment of atopic immune-related disorders, in pharmaceutical composition as well as in pharmaceutical preparation | BREAKTHROUGH MEDICAL RESEARCH B.V. (NL) | 2018-09-11 | — | — | US | disclosed |
| US-20170035735-A1 | Use Of Enoximone In The Treatment Of Atopic Immune-Related Disorders, In Pharmaceutical Composition As Well As In Pharmaceutical Preparation | BREAKTHROUGH MEDICAL RESEARCH B.V. (NL) | 2017-02-09 | — | — | US | disclosed |
| EP-0058435-B1 | NOVEL 4-AROYLIMIDAZOL-2-ONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-12-30 | — | — | EP | disclosed |
| EP-0059948-B1 | NOVEL AROYLIMIDAZOLONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1985-11-13 | — | — | EP | disclosed |
| US-4405628-A | 4-Pyridylimidazolones and method of use | MERRELL DOW PHARMACEUTICALS INC. (US) | 1983-09-20 | — | — | US | disclosed |
| US-4405635-A | HYPOTENSIVE, CARDIOTONIC, BRONCHODILATOR, ANTICOAGULANT, AND MUSCLE RELAXANT AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1983-09-20 | — | — | US | disclosed |
| EP-0059948-A1 | Novel aroylimidazolones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-09-15 | — | — | EP | disclosed |
| EP-0058435-A2 | Novel 4-aroylimidazol-2-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-08-25 | — | — | EP | disclosed |