SCHEMBL7436802

SCHEMBL7436802

CCOC(=O)C(CC)(CC(=O)O)CC(C)C

nearest known ligand 0.46

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MMP8 P22894 1/20 0.46
CYP4F2 P78329 2/20 0.45
CYP4A11 Q02928 2/20 0.45
EGLN1 Q9GZT9 1/20 0.33
MAPT P10636 1/20 0.33
PIN1 Q13526 1/20 0.33
PKM P14618 2/20 0.32
KDM4E B2RXH2 1/20 0.32
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
HTT P42858 2/20 0.32
HPGD P15428 1/20 0.32
ALDH1A1 P00352 3/20 0.31
POLB P06746 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
THRB P10828 1/20 0.31
LMNA P02545 1/20 0.30
HSD17B10 Q99714 1/20 0.30
CYP2D6 P10635 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27512517 0.93 MMP8 (0.49) MMP8CYP4F2CYP4A11EGLN1MAPT
SCHEMBL28712802 0.88 TSHR (0.38) MMP8CYP4F2CYP4A11ALDH1A1
SCHEMBL14417059 0.87 MMP8 (0.53) MMP8CYP4F2CYP4A11MAPTPIN1
SCHEMBL1244531 0.86 MMP8 (0.46) MMP8CYP4F2CYP4A11MAPTPKM
SCHEMBL20262480 0.85 CYP4F2 (0.53) CYP4F2CYP4A11EGLN1PIN1PKM
SCHEMBL19138766 0.83 CYP4F2 (0.46) MMP8CYP4F2CYP4A11EGLN1PIN1
SCHEMBL16415100 0.80 CYP2D6 (0.38) MEN1KMT2AALDH1A1THRBCYP2D6
SCHEMBL13278599 0.79 TSHR (0.41) MMP8MEN1KMT2AALDH1A1LMNA
SCHEMBL1246719 0.79 MMP8 (0.49) MMP8CYP4F2CYP4A11MAPTPKM
SCHEMBL3690855 0.79 TSHR (0.37) MMP8CYP4F2CYP4A11ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0664284-A1 Process for preparing carboxamides F. HOFFMANN-LA ROCHE AG (CH) 1995-07-26 EP claimed
EP-3580275-B1 HIGH MELT STRENGTH POLYPROPYLENES WITH IMPROVED PROCESSABILITY EXXONMOBIL CHEMICAL PATENTS INC (US) 2023-07-19 EP disclosed
CN-112300311-B Catalyst for olefin polymerization and olefin polymerization method 中国石油化工股份有限公司 2023-03-28 CN disclosed
US-11572462-B2 High melt strength polypropylenes with improved processability EXXONMOBIL CHEMICAL PATENTS INC. (US) 2023-02-07 US disclosed
US-11549006-B2 High melt strength polypropylene with high stiffness and clarity EXXONMOBIL CHEMICAL PATENTS INC. (US) 2023-01-10 US disclosed
US-11414526-B2 High melt strength polypropylene and extrusion process for preserving melt strength EXXONMOBIL CHEMICAL PATENTS INC. (US) 2022-08-16 US disclosed
CN-114230931-A High melt strength polypropylene and extrusion process for maintaining melt strength 埃克森美孚化学专利公司 2022-03-25 CN disclosed
CN-107417819-B Solid catalyst component for olefin polymerization, catalyst and application thereof 北京利和知信科技有限公司 2021-11-16 CN disclosed
CN-107417818-B Catalyst component for olefin polymerization, preparation method and catalyst 北京利和知信科技有限公司 2021-09-21 CN disclosed
WO-2021081660-A1 POLYMERIC FOAMS, METHODS, AND ARTICLES THEREOF EXXONMOBIL CHEMICAL PATENTS INC. (US) 2021-05-06 WO disclosed
EP-3160713-B1 HIGH MELT STRENGTH POLYPROPYLENE AND EXTRUSION PROCESS FOR PRESERVING MELT STRENGTH EXXONMOBIL CHEMICAL PATENTS INC (US) 2021-02-17 EP disclosed
US-20200325320-A1 High Melt Strength Polypropylene With High Stiffness And Clarity EXXONMOBIL CHEMICAL PATENTS INC (US) 2020-10-15 US disclosed
US-20200255641-A1 High Melt Strength Polypropylenes with Improved Processability EXXONMOBIL CHEMICAL PATENTS INC (US) 2020-08-13 US disclosed
US-20170210859-A1 HIGH MELT STRENGTH POLYPROPYLENE AND EXTRUSION PROCESS FOR PRESERVING MELT STRENGTH BASF SE (DE) 2017-07-27 US disclosed
EP-0664284-A1 Process for preparing carboxamides F. HOFFMANN-LA ROCHE AG (CH) 1995-07-26 EP disclosed