Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 5/20 | 0.42 |
| ▸ | PPARD | Q03181 | 3/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 2/20 | 0.34 |
| ▸ | VEGFA | P15692 | 3/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.33 |
| ▸ | CHRNG | P07510 | 1/20 | 0.33 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | CHRND | Q07001 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7424900 | 0.89 | PPARA (0.45) | PPARAPPARDPTGDR2FFAR1FFAR4 | |
| SCHEMBL7430025 | 0.75 | MAPT (0.44) | PTGDR2FFAR1 | |
| SCHEMBL6210766 | 0.72 | PPARG (0.50) | PPARAPPARDFFAR1PPARG | |
| SCHEMBL7432290 | 0.72 | KDM4E (0.36) | PTGDR2VEGFA | |
| SCHEMBL7428751 | 0.70 | SLC10A2 (0.35) | PPARDFFAR1PPARG | |
| SCHEMBL7431183 | 0.70 | FFAR1 (0.39) | PPARDPTGDR2FFAR1PPARG | |
| SCHEMBL24090486 | 0.69 | SLC6A4 (0.34) | PPARAPPARDCHRNA1CHRNGCHRNB1 | |
| SCHEMBL6808270 | 0.68 | PPARD (0.62) | PPARAPPARDPTGDR2FFAR1PPARG | |
| SCHEMBL7425055 | 0.67 | TP53 (0.32) | — | |
| SCHEMBL7426297 | 0.67 | CYP1A2 (0.40) | FFAR4HTTCHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0375451-A2 | Compounds having a renin-inhibiting activity | BEECHAM GROUP PLC (GB) | 1990-06-27 | — | — | EP | disclosed |
| EP-0350163-A2 | Renin inhibitory peptides | BEECHAM GROUP PLC (GB) | 1990-01-10 | — | — | EP | disclosed |