Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 5/20 | 0.50 |
| ▸ | CTSS | P25774 | 1/20 | 0.50 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.47 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.47 |
| ▸ | ACE | P12821 | 1/20 | 0.47 |
| ▸ | ECE1 | P42892 | 2/20 | 0.46 |
| ▸ | MME | P08473 | 1/20 | 0.46 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6897898 | 1.00 | CTSL (0.50) | CTSLCTSSSIRT2SIRT1FOLH1 | |
| SCHEMBL6534751 | 0.86 | ECE1 (0.61) | CTSLCTSSSIRT2SIRT1FOLH1 | |
| SCHEMBL12528507 | 0.85 | CTSL (0.53) | CTSLCTSSSIRT2SIRT1SIRT5 | |
| SCHEMBL6534777 | 0.85 | CTRB1 (0.59) | CTSLCTSSSIRT2SIRT1FOLH1 | |
| SCHEMBL4031333 | 0.85 | CTRB1 (0.59) | CTSLCTSSSIRT2SIRT1FOLH1 | |
| SCHEMBL4031330 | 0.85 | CTRB1 (0.59) | CTSLCTSSSIRT2SIRT1FOLH1 | |
| SCHEMBL8921335 | 0.85 | HDAC4 (0.51) | CTSLCTSSSIRT2SIRT1ECE1 | |
| SCHEMBL8921345 | 0.85 | HDAC4 (0.51) | CTSLCTSSSIRT2SIRT1ECE1 | |
| SCHEMBL8336670 | 0.84 | CTSL (0.58) | CTSLCTSSECE1MME | |
| SCHEMBL29473472 | 0.84 | TACR1 (0.61) | CTSLCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5627278-A | MULTISTAGE REACTION FORMED BY AMIDATION, COUPLING AND REDUCTION | BRISTOL-MYERS SQUIBB CO. (US) | 1997-05-06 | — | — | US | claimed |
| US-5627278-A | MULTISTAGE REACTION FORMED BY AMIDATION, COUPLING AND REDUCTION | BRISTOL-MYERS SQUIBB CO. (US) | 1997-05-06 | — | — | US | disclosed |
| US-5616775-A | ESTERIFYING A N-PROTECTED METHIONINE; OXIDIZING; REACTING WITH AN ACID ANHYDRIDE THEN AN ALKALI METAL HYDROXIDE | BRISTOL-MYERS SQUIBB CO. (US) | 1997-04-01 | — | — | US | disclosed |
| US-5508272-A | SELECTIVE ACE INHIBITORS, HYPOTENSIVE AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-04-16 | — | — | US | disclosed |
| EP-0629627-A2 | Bicyclic carboxylic acids and their derivatives as nep and aca inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-12-21 | — | — | EP | disclosed |